[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:1] [Pages No:0 - 0]
DOI: 10.5005/jsafog-6-2-x | Open Access | How to cite |
Abstract
• Ebola virus disease (EVD), also known as Ebola hemorrhagic fever, is a severe, often fatal illness of human beings having a case fatality rate of up to 90%. • Ebola virus disease outbreaks occur primarily in remote Central and West Africa, near the tropical rainforests. • The virus is transmitted to humans from wild animals and spreads in the human beings through physical contact. • It does not transmit through vectors or air-borne droplets. • Severely ill patients require intensive supportive care. No specific treatment or vaccine is available for use.
THE MOLECULAR DETAILS OF GESTATIONAL DIABETES MELLITUS: BEHAVIORAL PATTERNS OF PANCREATIC CELLS
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:1] [Pages No:0 - 0]
DOI: 10.5005/jsafog-6-2-vii | Open Access | How to cite |
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:1] [Pages No:0 - 0]
DOI: 10.5005/jsafog-6-2-v | Open Access | How to cite |
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:1] [Pages No:0 - 0]
DOI: 10.5005/jsafog-6-2-ix | Open Access | How to cite |
The Effect of Erythropoietin on Progesterone Levels during Ischemia Reperfusion Injury in Rats
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:6] [Pages No:65 - 70]
DOI: 10.5005/jp-journals-10006-1273 | Open Access | How to cite |
Pica in Rural Obstetric Population: An Underestimated Nutritional Mystery
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:4] [Pages No:71 - 74]
DOI: 10.5005/jp-journals-10006-1274 | Open Access | How to cite |
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:4] [Pages No:75 - 78]
DOI: 10.5005/jp-journals-10006-1275 | Open Access | How to cite |
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:4] [Pages No:79 - 82]
DOI: 10.5005/jp-journals-10006-1276 | Open Access | How to cite |
Seasonal Trends in the Occurrence of Eclampsia
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:5] [Pages No:83 - 87]
DOI: 10.5005/jp-journals-10006-1277 | Open Access | How to cite |
Single Step Test for Diagnosing Gestational Diabetes Mellitus
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:5] [Pages No:88 - 92]
DOI: 10.5005/jp-journals-10006-1278 | Open Access | How to cite |
H1N1 Influenza Virus Infection in Pregnancy: A Study of 32 Cases
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:5] [Pages No:93 - 97]
DOI: 10.5005/jp-journals-10006-1279 | Open Access | How to cite |
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:3] [Pages No:98 - 100]
DOI: 10.5005/jp-journals-10006-1280 | Open Access | How to cite |
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:3] [Pages No:101 - 103]
DOI: 10.5005/jp-journals-10006-1281 | Open Access | How to cite |
Infrared Coagulation of Benign Erosions of Cervix
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:3] [Pages No:104 - 106]
DOI: 10.5005/jp-journals-10006-1282 | Open Access | How to cite |
Urinary Incontinence: Revisited
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:5] [Pages No:107 - 111]
DOI: 10.5005/jp-journals-10006-1283 | Open Access | How to cite |
Vaginal Leiomyoma: A Rare Presentation
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:2] [Pages No:112 - 113]
DOI: 10.5005/jp-journals-10006-1284 | Open Access | How to cite |
Primary Amenorrhea in a Thalassemia Major
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:2] [Pages No:114 - 115]
DOI: 10.5005/jp-journals-10006-1285 | Open Access | How to cite |
Diprosopus: A Rare Conjoined Twin
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:2] [Pages No:116 - 117]
DOI: 10.5005/jp-journals-10006-1286 | Open Access | How to cite |
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:5] [Pages No:118 - 122]
DOI: 10.5005/jp-journals-10006-1287 | Open Access | How to cite |
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:3] [Pages No:123 - 125]
DOI: 10.5005/jp-journals-10006-1288 | Open Access | How to cite |
Malignant Brenner Tumor of Ovary
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:3] [Pages No:126 - 128]
DOI: 10.5005/jp-journals-10006-1289 | Open Access | How to cite |
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:2] [Pages No:129 - 130]
DOI: 10.5005/jsafog-6-2-129 | Open Access | How to cite |
Abstract
Polycystic ovary syndrome (PCOS) is a common endocrine disorder of premenopausal women, characterized by hyperandrogenism, polycystic ovaries, and chronic anovulation along with insulin resistance and abdominal obesity as frequent metabolic traits. Although, PCOS manifests clinically during adolescence, emerging data suggest that the natural history of PCOS may originate in intrauterine life. Evidence from experimental, clinical, and genetic research supporting the hypothesis for the fetal origins of PCOS has been analyzed. Female primates, exposed in utero to androgen excess, exhibit the phenotypic features of PCOS during adult life. Clinical observations also support a potential fetal origin of PCOS. Women with fetal androgen excess disorders, including congenital 21-hydroxylase deficiency and congenital adrenal virilizing tumors, develop features characteristic of PCOS during adulthood despite the normalization of androgen excess after birth. The potential mechanisms of fetal androgen excess leading to a PCOS phenotype in humans are not clearly understood. However, maternal and/or fetal hyperandrogenism can provide a plausible mechanism for fetal programming of PCOS, and this, in part, may be genetically determined. Thus, genetic association studies have indicated that common polymorphic variants of genes determining androgen activity or genes that influence the availability of androgens to target tissues are associated with PCOS and increased androgen levels. These genomic variants may provide the genetic link to prenatal androgenization in human PCOS. Prenatal androgenization of the female fetus induced by genetic and environmental factors, or the interaction of both, may program differentiating target tissues toward the development of PCOS phenotype in adult life.
Principles and Practice of Obstetrics and Gynecology for Postgraduates
[Year:2014] [Month:May-August] [Volume:6] [Number:2] [Pages:1] [Pages No:131 - 131]
DOI: 10.5005/jsafog-6-2-131 | Open Access | How to cite |