Aims and background: Menopause alters the lipid profile by raising total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL C), and very low-density lipoprotein cholesterol (VLDL C) while lowering high-density lipoprotein cholesterol (HDL C). In women with cardiovascular risk linked to interleukin-6 (IL-6) and C-reactive protein (CRP) plasma levels, this study aimed to examine the connection between IL-6 levels and lipid profiles in both menopausal and reproductive women with coronary artery disease (CAD). Age, body mass index (BMI), smoking history, blood pressure, alcohol consumption, diabetes, and exercise frequency were found to be related to IL-6 concentrations. Materials and methods: Observational analytical study with a case-control design was used in this study. Two groups (menopausal and reproductive women) of 44 women had their IL-6 levels and lipid profile checked. The data were then analyzed using a correlation test. Results: The BMI, smoking behaviors, and family history of heart disease were observed to significantly differ between the menopausal and reproductive groups of women (p < 0.05). In both groups, there was a substantial relationship (p < 0.05) between IL-6 levels and lipid markers such as TC, LDL, and TG. The HDL levels did not differ statistically significantly (p > 0.05) between the two groups, however. The length of menopause and IL-6 levels were significantly correlated in the group of menopausal women (p < 0.05). Conclusion: The lipid profile (total cholesterol, LDL, and triglycerides) and IL-6 levels were significantly correlated in menopausal women and reproductive women with CAD. Clinical significance: Elevated IL-6 is associated with disturbance of lipid profile among both menopausal and reproductive women with CAD.