Favorable Feto-maternal Outcome in a Case of Chronic Deep Vein Thrombosis Patient due to Protein S Deficiency: A Case Report
Bindusri Madhavi, Neetha Nandan, Neetha Poonja, Supriya Rai
Keywords :
Case report, Chronic deep vein thrombosis, Protein S deficiency, Thromboprophylaxis
Citation Information :
Madhavi B, Nandan N, Poonja N, Rai S. Favorable Feto-maternal Outcome in a Case of Chronic Deep Vein Thrombosis Patient due to Protein S Deficiency: A Case Report. J South Asian Feder Obs Gynae 2024; 16 (6):699-701.
Background: Protein S (PS) deficiency is an inherited thrombophilia and is inherited as autosomal dominant form. When it occurs in pregnancy, there may be adverse outcomes for both the mother and the fetus. Mother can have recurrent thromboembolic episodes and recurrent pregnancy loss (RPL), while baby can have fatal condition like purpura fulminans (PF) when it occurs in homozygous state.
Case description: We present to you a case of chronic deep vein thrombosis from the past 2 years which was diagnosed to be due to PS deficiency. While she was on oral anticoagulant thromboprophylaxis (Dabigatrin), she had conceived spontaneously. During her antenatal period, she was prescribed low molecular weight heparin thromboprophylaxis (Enoxaprin) throughout pregnancy. She underwent an emergency cesarean section and had a good pregnancy and fetal outcome.
Clinical significance: Anticoagulation therapy plays a vital role in achieving a successful pregnancy outcome in cases of inherited thrombophilias.
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