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VOLUME 16 , ISSUE S2 ( August, 2024 ) > List of Articles

CASE REPORT

Beyond Boundaries: Navigating Vulvar Verrucous Carcinoma and Lupus on a Shared Path

Ramith P Shetty, Sonal Fernandes, Jacintha Martis, Jyothi Jayaraman

Keywords : Case report, Systemic lupus erythematosus, Vulvar cancer, Vulvar verrucous carcinoma

Citation Information :

DOI: 10.5005/jp-journals-10006-2481

License: CC BY-NC 4.0

Published Online: 02-09-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

Vulvar verrucous carcinoma (VC) is a rather uncommon type of genital cancer which presents as an invasive, locally restricted, slow-growing tumor. We describe a case of a female in her late 50s who was a diagnosed case of systemic lupus erythematosus (SLE), idiopathic thrombocytopenic purpura presenting with vulvar VC. Risk factors associated with VC are human papilloma virus (HPV) infection, hormonal imbalances, and diabetes mellitus. This patient was immunosuppressed which made her susceptible toward malignancy. This case report represents the intricate interplay between malignancy and autoimmune disorders.

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  1. Campaner AB, Cardoso FA, Fernandes GL, et al. Verrucous carcinoma of the vulva: Diagnosis and treatment. An Bras Dermatol 2017;92: 243–245. DOI: 10.1590/abd1806-4841.20174929.
  2. Japaze H, Van Dinh T, Woodruff JD. Verrucous carcinoma of the vulva: Study of 24 cases. Obstet Gynecol 1982;60:462–466. PMID: 7121933.
  3. Tornes K, Bang G, Strømme Koppang H, et al. Oral verrucous carcinoma. Int J Oral Surg 1985;14:485–492. DOI: 10.1016/s0300-9785(85)80054-5.
  4. Bouquet de Jolinière J, Khomsi F, Gothuey JM, et al. Verrucous carcinoma of the vulva: A case report and review of the literature. Front Surg 2016;3:8. DOI: 10.3389/fsurg.2016.00008.
  5. Bhati I, Rana S, Sharma A. A rare variety of vulval carcinoma-verrucous carcinoma: A case report. J South Asian Feder Menopause Soc 2018;6:122–124. DOI: 10.1097/PGP.0b013e318166fd79.
  6. Crowther ME, Shepherd JH, Fisher C. Verrucous carcinoma of the vulva containing human papilloma virus. 11 cases report. Br J Obstet Gynaecol 1988;95:414–418. PMID: 6095166.
  7. Rubio D, Moratalla E, Camarasa N, et al. Carcinoma verrucoso de vulva. Clin Invest Gin Obst 2006;33:241–243. DOI: 10.1016/S0210-573X(06)74125-9.
  8. Dreyer L, Faurschou M, Mogensen M, et al. High incidence of potentially virus-induced malignancies in systemic lupus erythematosus: A long-term follow up study in a Danish cohort. Arthritis Rheum 2011;63:3032–3037. DOI: 10.1002/art.30483.
  9. Zard E, Arnaud L, Mathian A, et al. Increased risk of high grade cervical squamous cell intraepithelial lesions in systemic lupus erythematosus: A meta-analysis of the literature. Autoimmune Rev 2014;13:730–735. DOI: 10.1016/j.autrev.2014.03.001.
  10. Lyrio LDC, Grassi MFR, Santana IU, et al. Prevalence of cervical human papillomavirus infection in women with systemic lupus erythematosus. Rheumatol Int 2013;33:335–340. DOI: 10.1007/s00296-012-2426-0.
  11. Vîlcea AM, Stoica LE, Cernea N, et al. Vulvar verrucous carcinoma and genital condylomatosis. Curr Health Sci J 2021;47:602–607. DOI: 10.12865/CHSJ.47.04.19.
  12. Rivero RC, Garcia D, Hammes LS, et al. Carcinogenesis of vulvar lesions: Morphology and immunohistochemistry evaluation. J Low Genit Tract Dis 2017;21:73–77. DOI: 10.1097/LGT.0000000000000271.
  13. Santos M, Montagut C, Mellado B, et al. Immunohistochemical staining for p16 and p53 in premalignant and malignant epithelial lesions of the vulva. Int J Gynecol Pathol 2004;23:206–214. DOI: 10.1097/01.pgp.0000130108.03231.89.
  14. Boyce J, Fruchter RG, Kasambilides E, et al. Prognostic factors in carcinoma of the vulva. Gynecol Oncol 1985;20:364–377. DOI: 10.1016/0090-8258(85)90218-5.
  15. Tateo A, Tateo S, Bernasconi C, et al. Use of V-Y flap for vulvar reconstruction Gynecol Oncol 1996;62:203–207. DOI: 10.1006/gyno.1996.0216.
  16. Dryden SM, Reshko LB, Gaskins JT, et al. Verrucous carcinoma of the vulva: Patterns of care and treatment outcomes. Cancer Rep 2022;5:e21591. DOI: 10.1002/cnr2.1591.
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