Introduction: A thin endometrium is a significant contributor to failed embryo implantation. A considerable percentage of women who have thin endometrium are resistant to conventional therapeutic approaches. Administering platelet-rich plasma (PRP) directly into the uterus can potentially augment the thickness and vascularity of the endometrium, thereby enhancing its receptivity and encouraging embryo implantation. Human chorionic gonadotropin (HCG) plays a crucial paracrine role during implantation of embryos. This research aimed to compare the efficacy of PRP and HCG in patients who had previously had unsuccessful implantation. Materials and methods: A retrospective study was conducted at Wardha Test Tube Baby Centre, Sawangi (Meghe), Wardha, over 1 year. About 40 infertile women with previously failed implantation undergoing frozen-thawed embryo transfer who have a persistently thin endometrial lining (< 7 mm) despite standard hormone replacement therapy were given intrauterine PRP or intrauterine HCG injection and were analyzed and compared. An increment in endometrial thickness (ET) and obstetric outcomes were assessed. Results: Among the cases assessed, group A exhibited a significantly higher mean ET (7.72 ± 0.33) after intrauterine PRP infusion than group B (7.35 ± 0.31) with intrauterine HCG infusion (p-value –0.001). The distribution of implantation rate, clinical pregnancy rate (CPR), and live birth rate was considerably more in the PRP cohort (75, 54.2, and 80%, respectively) than in the HCG group (40, 30.2, and 45%, respectively) (p-value < 0.05). Amidst the two groups, there were no appreciable variations in the distribution of the biochemical pregnancy rate (BPR) and miscarriage rate (p-value > 0.05). Conclusion: With intrauterine PRP administration, ET significantly increased along with notable improvements in CPR, IR, and live birth rates (LBR). In our study, the cycle cancellation rate was zero.