Journal of South Asian Federation of Obstetrics and Gynaecology

Register      Login

VOLUME 16 , ISSUE 3 ( May-June, 2024 ) > List of Articles


A Case of Leiomyosarcoma of Vaginal Vault in a Post-hysterectomy Patient

Agniv Sarkar, Manoranjan Mahapatra, Jita Parija, Smruthisudha Pattnaik

Keywords : Case report, Leiomyosarcoma, Pelvic mass, Smooth muscle antigen-positive leiomyosarcoma, Spindle cell carcinoma

Citation Information : Sarkar A, Mahapatra M, Parija J, Pattnaik S. A Case of Leiomyosarcoma of Vaginal Vault in a Post-hysterectomy Patient. J South Asian Feder Obs Gynae 2024; 16 (3):313-314.

DOI: 10.5005/jp-journals-10006-2032

License: CC BY-NC 4.0

Published Online: 29-04-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Leiomyosarcoma usually arises de novo from uterine smooth muscle, although it may rarely arise from a preexisting leiomyoma. They are usually accompanied by pain, sensation of pressure, and abnormal uterine bleeding (AUB). Rapid enlargement of fibroid or rapidly increasing pain may be a symptom too. In this case, a 62-year-old woman came to the outpatient department (OPD) with a complaint of pain abdomen for the last 3 months. She is (P2L2), post-menopausal for the last 12 years. She had a history of total abdominal hysterectomy (TAH) + bilateral salpingo-oophorectomy (BSO) 10 years back. On examination, she had a pelvic mass of 8 × 6 cm solid variegated. Outside, fine needle aspiration cytology (FNAC) report revealed it to be a spindle cell carcinoma. In our institute, tumor markers came out to be normal and contrast-enhanced computed tomography (CECT) imaging suggested a solid mass arising from vaginal vault. On laparotomy, a solid mass of 8 × 8 cm was found attached to the vaginal vault. All other organs were normal. Final holoprosencephaly (HPE) report came out to be leiomyosarcoma with immunohistochemistry (IHC) of smooth muscle antigen (SMA)-positive.

PDF Share
  1. Forney JP, Buschbaum HJ. Classifying staging and treating uterine sarcomas. Contemporary Ob Gyn 1981;18(3):47–69. NII Article ID: 10017494254.
  2. Norris HJ, Zalouder CJ. Mesenchymal tumour of uterus. In: Blaustein A, editor. Pathology of female genital tract. 2nd ed. New York: Springer-Verlag Books; 1982. pp. 352–392.
  3. Echt G, Jepson J, Steel J, et al. Treatment of uterine sarcomas. Cancer 1990;66:35–39. DOI: 10.1002/1097-0142.
  4. Major FJ, Blessing JA, Silverberg SG, et al. Prognostic factors in early stage uterine sarcoma. A gynaecologic oncology group study. Cancer 1993;71(4):1702–1709. DOI: 10.1002/cncr.2820710440.
  5. Evans HL, Chawla SP, Simpson C, et al. Smooth muscle neoplasms of the uterus other than ordinary leiomyoma. A study of 46 cases, with emphasis on diagnostic criteria and prognostic factors. Cancer 1988;62(10): 2239–2247. DOI: 10.1002/1097-0142(19881115)62:10<2239::aid-cncr 2820621028>;2-y.
  6. D'Angelo E, Prat J. Uterine sarcomas: A review. Gynecol Oncol 2010;116(1):131–139. DOI: 10.1016/j.ygyno.2009.09.023.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.