Citation Information :
Bhalerao KV, Pajai S. Maternal Serum Anti-Müllerian Hormone Levels as Predictor of Preeclampsia. J South Asian Feder Obs Gynae 2023; 15 (5):575-579.
Aim: This study aims at finding the association of serum anti-Müllerian hormone (AMH) levels at 11–14 weeks of gestation in the prediction of preeclampsia.
Materials and methods: Antenatal patients between 11 and 14 weeks of gestation were recruited after providing written informed consent. Serum AMH was done for all patients. They were then categorized into the low AMH group and the normal AMH group. They were followed for the development of preeclampsia till 7 days postpartum and the pregnancy outcomes of both groups were compared.
Conclusion: The occurrence of preeclampsia in patients with normal AMH levels was low accounting for 34.4% compared to patients with low AMH levels where preeclampsia was 65.6%. The occurrence of preeclampsia at a tertiary care hospital was 16.6%. The frequency of preeclampsia in patients with low AMH was 9 times higher than normal AMH levels. Thus, low AMH levels at 11–14 weeks can predict preeclampsia so should be incorporated into first-trimester screening.
Clinical significance: Biomarker maternal serum AMH has recently been related to preeclampsia and its connection with the placenta and heart muscle would suggest its role in preeclampsia and cardiovascular risk later in the life of women with low AMH levels.
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