Citation Information :
Deedwania P, Shrivastava V, Gupta B. Use of Oxidized Regenerated Cellulose in Vaginoplasty Surgeries: Review of Safety, Vaginal Epithelization, and Sexual Satisfaction. J South Asian Feder Obs Gynae 2023; 15 (2):224-229.
Introduction: Vaginal agenesis is an uncommon condition. This may occur as an isolated developmental anomaly or may be associated with other anomalies. Vaginal agenesis can impose immense psychological stress on a woman. The aim of vaginoplasty is to create a neovagina that has a satisfactory appearance, function, and feeling. A perineal approach with various surgical modifications is the most commonly performed technique. However, the material of graft varied from bowel transplants, thigh or subcutaneous abdominal flaps, split-thickness skin grafts, amnion, and oxidized regenerated cellulose etc. among various studies.
Review: The electronic databases (PubMed, Google Scholar) were searched using a combination of the following search terms “Vaginoplasty”, “Neovagina”, and “oxidized regenerated cellulose”. The thirteen full-text case reports/series on epithelization of a neovagina using oxidized regenerated cellulose in vaginoplasty surgeries were reviewed.
Discussion: The use of oxidized regenerated cellulose during vaginoplasty as a graft substitute can provide good surgical results such as epithelization of a neovagina, vaginal length achieved, and satisfactory sexual intercourse after surgery, without increasing the risk of operative complications and late post-operative complications.
Conclusion: Vaginal reconstructive surgery using oxidized regenerated cellulose for epithelization is a simple, safe, and effective technique with promising results in terms of epithelization, achieving adequate vaginal length, and satisfactory sexual intercourse.
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