Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 14 , ISSUE 4 ( July-August, 2022 ) > List of Articles

Original Article

A Comparative Study of Bacterial Vaginosis in Preterm and Term Labor

Kanan P Kotdawala, Manjusha Agrawal, Parul Kotdawala

Keywords : Amsel's criteria, Anemia, Bacterial vaginosis, Lower socioeconomic class, Preterm labor

Citation Information : Kotdawala KP, Agrawal M, Kotdawala P. A Comparative Study of Bacterial Vaginosis in Preterm and Term Labor. J South Asian Feder Obs Gynae 2022; 14 (4):361-364.

DOI: 10.5005/jp-journals-10006-2091

License: CC BY-NC 4.0

Published Online: 22-08-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Purpose: Is there a difference in association of bacterial vaginosis (BV) with preterm labor as compared to term labor? Successful treatment of BV during pregnancy may reduce the incidence of preterm birth as low as 50%. It is important to work toward predicting, and diagnosing the causative factors, and finally taking steps to minimize the preterm deliveries which is of utmost priority in developing countries like India. Therefore, this study is carried out to analyze the occurrence of BV in preterm and term labor. Materials and methods: This cross-sectional study of 100 laboring women in each group divided in to two groups depending on the gestational age into preterm group and term group and was carried out in a tertiary care center over 2 years (from September 2019 to September 2021) using non-probability simple random sampling technique. The women of both groups were independently segregated as those who fulfilled Amsel's criteria (≥3 out of 4) and those who did not. Results: In this study, the incidence of BV was found to be 38% in preterm group and 13% in the term group with χ2 = 16.449, p = 0.00005, and odds ratio (OR) = 4.1, that is, OR >1 with the whiff test being most sensitive among four criteria of Amsel's. Conclusion: Bacterial vaginosis was noted more frequently in women with preterm labor compared to women in term labor. There was a significant impact of socio-demographic factors on occurrence. Amsel's criteria should be utilized as a low cost, easily available screening-diagnostic tool in symptomatic women.

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  1. Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med 2000 May 18;342(20):1500–1507. DOI: 10.1056/NEJM200005183422007.
  2. Lamont RF, Anthony F, Myatt L, et al. Production of prostaglandin E2 by human amnion in vitro in response to addition of media conditioned by microorganisms associated with chorioamnionitis and preterm labor. Am J Obstet Gynecol 1990;162(3):819–825. DOI: 10.1016/0002-9378(90)91017-7.
  3. Koumans EH, Kendrick JS, CDC Bacterial Vaginosis Working Group. Preventing adverse sequelae of bacterial vaginosis: a public health program and research agenda. Sex Transm Dis 2001 May;28(5):292–297. DOI: 10.1097/00007435-200105000-00011.
  4. Ranjan S, Mohapatra I, Sahoo G. Study of association of bacterial vaginosis and preterm labour in a tertiary care hospital. Perspect Clin Res 2015; 3(3):6–10.
  5. Nelson DB, Hanlon A, Hassan S, et al. Preterm labor and bacterial vaginosis-associated bacteria among urban women. J Perinat Med 2009;37(2):130–134. DOI: 10.1515/JPM.2009.026.
  6. Cammack AL, Buss C, Entringer S, et al. The association between early life adversity and bacterial vaginosis during pregnancy. Am J Obstet Gynecol 2011;204(5):431.e1–431.e8. DOI: 10.1016/j.ajog.2011.01.054.
  7. Sudha AC, Teja GK. Study on bacterial vaginosis in pregnant women and associated factors on maternal and fetal outcome. Int J Reprod Contracept Obstet Gynecol 2019;8(9):3459–3465. DOI: 10.18203/2320-1770.ijrcog20193693.
  8. Peacock JL, Bland JM, Anderson HR. Preterm delivery: effects of socioeconomic factors, psychological stress, smoking, alcohol, and caffeine. BMJ 1995;311(7004):531–535. DOI: 10.1136/bmj.311.7004.531.
  9. Dingens AS, Fairfortune TS, Reed S, et al. Bacterial vaginosis and adverse outcomes among full-term infants: a cohort study. BMC Pregnancy Childbirth 2016;16(1):278. DOI: 10.1186/s12884-016-1073-y.
  10. Yzeiraj–Kalemaj L, Shpata V, Vyshka G, et al. Bacterial vaginosis, educational level of pregnant women, and preterm birth: a case–control study. ISRN Infect Dis 2013;2013:e980537. DOI: 10.5402/2013/980537.
  11. Brookheart RT, Lewis WG, Peipert JF, et al. Association between obesity and bacterial vaginosis as assessed by Nugent score. Am J Obstet Gynecol 2019;220(5):476.e1–476.e11. DOI: 10.1016/j.ajog.2019.01.229.
  12. Purwar M, Ughade S, Bhagat B, et al. Bacterial vaginosis in early pregnancy and adverse pregnancy outcome. J Obstet Gynaecol Res 2001;27(4):175–181. DOI: 10.1111/j.1447-0756.2001.tb01248.x.
  13. Donders GG, Van Bulck B, Caudron J, et al. Relationship of bacterial vaginosis and mycoplasmas to the risk of spontaneous abortion. Am J Obstet Gynecol 20001;183(2):431–437. DOI: 10.1067/mob.2000.105738.
  14. Sumati AH, Saritha NK. Association of urinary tract infection in women with bacterial vaginosis. J Glob Infect Dis 2009;1(2):151–152. DOI: 10.4103/0974-777X.56254.
  15. Harmanli OH, Cheng GY, Nyirjesy P, et al. Urinary tract infections in women with bacterial vaginosis. Obstet Gynecol 2000;95(5):710–712. DOI: 10.1016/s0029-7844(99)00632-8.
  16. Neggers YH, Nansel TR, Andrews WW, et al. Dietary intake of selected nutrients affects bacterial vaginosis in women. J Nutr 2007;137(9):2128–2133. DOI: 10.1093/jn/137.9.2128.
  17. Chaijareenont K, Sirimai K, Boriboonhirunsarn D, et al. Accuracy of Nugent's score and each Amsel's criteria in the diagnosis of bacterial vaginosis. J Med Assoc Thail Chotmaihet Thangphaet 2004;87(11):1270–1274. PMID: 15825698.
  18. Shukla S. To study the role of bacterial vaginosis as a risk factor for preterm labour. IJSR 2022. Available from: DOI: 10.36106/ijsr.
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