Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 14 , ISSUE 2 ( March-April, 2022 ) > List of Articles


High Morbidity of Preterm Neonates in Pregnancy with Preeclampsia: A Retrospective Study in Indonesia

Sri Pamungkas, Rima Irwinda, Noroyono Wibowo

Keywords : Perinatal outcome, Preeclampsia, Preterm labor

Citation Information : Pamungkas S, Irwinda R, Wibowo N. High Morbidity of Preterm Neonates in Pregnancy with Preeclampsia: A Retrospective Study in Indonesia. J South Asian Feder Obs Gynae 2022; 14 (2):157-160.

DOI: 10.5005/jp-journals-10006-2023

License: CC BY-NC 4.0

Published Online: 21-06-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Background: Preeclampsia is a leading cause of preterm birth, accompanied by compelling maternal and neonatal morbidities. This study aims to investigate preterm neonate outcomes in pregnancy with preeclampsia. Materials and methods: A retrospective observational study was conducted in Indonesia's national referral hospital. Infants born <37 weeks from January 2015 to December 2018 were recruited, both from preeclamptic and non-preeclamptic mothers. The measured outcomes were necrotizing enterocolitis (NEC), hypoxic–ischemic encephalopathy (HIE), respiratory distress syndrome (RDS), as well as bronchopulmonary dysplasia (BPD). Results: There were 2,750 preterm neonates enrolled in this study, with 455 neonates born from mothers with preeclampsia. Neonates in the preeclampsia group had a higher incidence of NEC (OR [odds ratio] 2.22; 95% CI [confidence interval] 1.5–3.17), HIE (OR 3.84; 95% CI 1.61–9.17), RDS (OR 5.51; 95% CI 4.35–6.98), and BPD (OR 1.87; 95% CI 1.03–3.42). Conclusion: Neonatal morbidities, such as NEC, HIE, RDS, and BPD, were found higher in preterm neonates born from preeclamptic mothers compared to uncomplicated pregnant women.

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