Distribution and Prevalence of High-risk Human Papillomavirus Infection in Women of Western Uttar Pradesh, India: A Hospital-based Study
Ruchi Mishra, Dakshina Bisht, Manisha Gupta
Cervical cancer, High-grade squamous intraepithelial lesion, Human papillomavirus DNA, Human papillomavirus vaccines, Low-grade squamous intraepithelial lesion, Pap smear
Citation Information :
Mishra R, Bisht D, Gupta M. Distribution and Prevalence of High-risk Human Papillomavirus Infection in Women of Western Uttar Pradesh, India: A Hospital-based Study. J South Asian Feder Obs Gynae 2022; 14 (2):91-94.
Aim: Cervical cancer caused by human papillomavirus (HPV) is heterogenic in nature with a regional variation in its distribution. It is crucial to detect high-risk HPV, and thus, the present study aims to find the distribution and prevalence of HPV genotypes by DNA testing and its correlation with cervical cytology. The results of this study would be helpful in the development of newer and efficacious HPV vaccine to make it regionally more specific.
Materials and methods: A cross-sectional study was conducted in a tertiary-care hospital. A total of 217 women presented at the outpatient Department of Obstetrics and Gynaecology with different clinical conditions. Women with history of malignancy and pregnancy were excluded from the study. Detailed history was taken on a preformed pro forma, and cervical samples were detected for abnormal cytology by Pap smear and genotyping by HPV DNA testing by polymerase chain reaction.
Results: The overall prevalence of HPV was 5.5% (12/217), and HPV types 59, 56, 51, 33 and 18 were found prevalent in this study. The higher number of HPV DNA positivity found was in low-grade squamous intraepithelial lesion constituting (66.6%), followed by inflammatory smear (20.6%) and normal cytology with (1.1%).
Conclusion: It has been observed that there is a high prevalence of HPV genotypes 59, 56, 51, 33, and 18. Our study highlights the importance of considering other high-risk genotypes which are not covered by the vaccines currently available in India; therefore, it is necessary to redesign the vaccine by including these genotypes to reduce the incidence of carcinoma cervix.
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