Aim and objective: To determine the correlation of serum uric acid and serum calcium with the severity of preeclampsia and eclampsia.
Materials and methods: The present case-control study has been carried out for a period of 1 year from March 2018 to February 2019 after institutional ethical clearance. The sample size of the study was 150 cases and 150 controls. This was a case-control study. Cases were admitted patients with preeclampsia or eclampsia. Controls were normotensive pregnant women. On admission, after informed consent, venous serum samples were collected prior to their commencement of intravenous therapy and magnesium sulfate therapy. Blood samples obtained on admission were sent for serum calcium and serum uric acid level estimation, and then, the results were analyzed.
Result: The mean serum uric acid among cases was 6.98 ± 1.85 mg/dL, whereas in controls, it was 4.55 ± 1.38 mg/dL; similarly, the mean serum calcium among cases and controls was 8.44 ± 1.1 and 9.87 ± 0.69, respectively. Test of significance observed statistically highly significant difference in mean serum uric acid and serum calcium between cases and controls (p <0.01). The present study observed a significantly higher occurrence of cerebrovascular accident (CVA), and postpartum hemorrhage (PPH) among cases with serum uric acid level greater than 6.2 mg/dL as compared to cases with serum uric acid level less than 6.2 mg/dL (p <0.05). The present study observed that CVA was significantly higher in cases with serum calcium level less than 9 mg/dL (p <0.05). The occurrence of deaths due to pulmonary embolism (PE), pulmonary edema, acute respiratory distress syndrome (ARDS), and multiple organ dysfunction syndrome (MODS) was higher in patients with raised serum uric acid level.
Conclusion: The present study found that elevated serum uric acid level could be used as a biochemical marker for preeclampsia and eclampsia. Calcium supplement may help in the reduction of incidence of preeclampsia and eclampsia in country especially where nutrition is poor.
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