Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 13 , ISSUE 2 ( March-April, 2021 ) > List of Articles

Original Article

Correlation of the Levels of Vitamin D with Size of Leiomyoma in a 450-bedded Maternity Hospital of Delhi

Vinita Sarbhai, Sangita N Ajmani, Shobhika Singh

Keywords : Fibroid uterus, Leiomyoma uteri, Vitamin D

Citation Information : Sarbhai V, Ajmani SN, Singh S. Correlation of the Levels of Vitamin D with Size of Leiomyoma in a 450-bedded Maternity Hospital of Delhi. J South Asian Feder Obs Gynae 2021; 13 (2):77-80.

DOI: 10.5005/jp-journals-10006-1869

License: CC BY-NC 4.0

Published Online: 09-07-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Introduction: The pathogenesis of fibroids has been hypothesized to involve a positive feedback loop between extracellular matrix production and cell proliferation, and vitamin D might act to block the positive feedback. Hence, this study was carried out to know the correlation of vitamin D levels with the size of fibroids. Methods: Seventy-five patients diagnosed with leiomyoma on ultrasound scan were labeled as the case group. Control group comprised of 75 women whose pelvic ultrasound was normal and there was no fibroid. On trans-vaginal sonography (TVS), we measured the volume of each of them. The quantitative detection of serum vitamin D levels was performed using a kit based on chemiluminescence in cases and control. Results: The mean value of vitamin D levels in cases was 12.58 + 4.09 ng/mL while in controls it was 18.99 + 5.72 ng/mL with p-value <0.001. Thus it was statistically significantly lower in cases than in controls. Pearson correlation of total volume of the fibroid (cm3) and vitamin D level (ng/mL) was −0.292 with p-value of 0.011. Conclusion: The volume of fibroid and serum vitamin D levels are inversely related to each other, i.e., the less is the vitamin D levels, the more will be the volume of the fibroid.

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