Correlation of the Levels of Vitamin D with Size of Leiomyoma in a 450-bedded Maternity Hospital of Delhi
Vinita Sarbhai, Sangita N Ajmani, Shobhika Singh
Fibroid uterus, Leiomyoma uteri, Vitamin D
Citation Information :
Sarbhai V, Ajmani SN, Singh S. Correlation of the Levels of Vitamin D with Size of Leiomyoma in a 450-bedded Maternity Hospital of Delhi. J South Asian Feder Obs Gynae 2021; 13 (2):77-80.
Introduction: The pathogenesis of fibroids has been hypothesized to involve a positive feedback loop between extracellular matrix production and cell proliferation, and vitamin D might act to block the positive feedback. Hence, this study was carried out to know the correlation of vitamin D levels with the size of fibroids.
Methods: Seventy-five patients diagnosed with leiomyoma on ultrasound scan were labeled as the case group. Control group comprised of 75 women whose pelvic ultrasound was normal and there was no fibroid. On trans-vaginal sonography (TVS), we measured the volume of each of them. The quantitative detection of serum vitamin D levels was performed using a kit based on chemiluminescence in cases and control.
Results: The mean value of vitamin D levels in cases was 12.58 + 4.09 ng/mL while in controls it was 18.99 + 5.72 ng/mL with p-value <0.001. Thus it was statistically significantly lower in cases than in controls. Pearson correlation of total volume of the fibroid (cm3) and vitamin D level (ng/mL) was −0.292 with p-value of 0.011.
Conclusion: The volume of fibroid and serum vitamin D levels are inversely related to each other, i.e., the less is the vitamin D levels, the more will be the volume of the fibroid.
Holick MF. Vitamin D deficiency. N Engl J Med 2007;357(3):266–281. DOI: 10.1056/NEJMra070553.
Leppert PC, Catherino WH, Segars JH. A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays. Am J Obstet Gynecol 2006;195(2):415–420. DOI: 10.1016/j.ajog.2005.12.059.
Sabry M, Al-Hendy A. Innovative oral treatments of uterine leiomyoma. Obstet Gynecol Int 2012;2012:943–963. DOI: 10.1155/2012/943635.
Sharan C, Halder SK, Thota C, et al. Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase. Fertil Steril 2011;95(1):247–253. DOI: 10.1016/j.fertnstert.2010.07.1041.
Halder S, Sharan C, Al-Hendy A. Vitamin D treatment induces dramatic shrinkage of uterine leiomyomas growth in the Eker rat model. Fertil Steril 2010;94(4):S75–S76. https://doi.org/10.1016/j.fertnstert.2010.07.293
Deeb KK, Trump DL, Johnson CS. Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer 2007;7(9):684–700. DOI: 10.1038/nrc2196.
Bläuer M, Rovio PH, Ylikomi T, et al. Vitamin D inhibits myometrial and leiomyoma cell proliferation in vitro. Fertil Steril 2009;91(5):1919–1925. DOI: 10.1016/j.fertnstert.2008.02.136.
Halder SK, Goodwin JS, Al-Hendy A. 1,25-Dihydroxyvitamin D3 reduces TGF-beta3-induced fibrosis-related gene expression in human uterine leiomyoma cells. J Clin Endocrinol Metab 2011;96(4):E754–E762. DOI: 10.1210/jc.2010-2131.
Ingala P, Mboloko J, Tshiband A, Lepira F, Kayembe P, Lebwaze B, et al. Vitamin D Deficiency and Risk of Uterine Leiomyoma among Congolese Women. A Hospital-Based Case-Control Study. American Scientific Research Journal for Engineering, Technology, and Sciences (ASRJETS) (2016) Volume 22, No 1, pp 126-137.
Sabry M, Halder SK, Ait Allah ASA, et al. Serum vitamin D3 level inversely correlates with uterine fibroid volume in different ethnic groups: a cross-sectional observational study. Int J Womens Health 2013;5(1):93–100. DOI: 10.2147/IJWH.S38800.
Ciavattini A, Carpini GD, Serri M, et al. Hypovitaminosis D and “small burden” uterine fibroids: opportunity for a vitamin D supplementation. Medicine (United States) 2016;95(52):e5698. DOI: 10.1097/MD.0000000000005698.