Premature rupture of membrane (PROM) has significant adverse events in the prenatal, peripartum, and neonatal period. Understanding the maternal and neonatal outcomes of PROM is very important to reduce maternal and child mortality by prevention of complications and better management of the condition. The present study is undertaken to determine the maternal and fetal outcomes in patients with PROM and factors influencing the maternal and neonatal outcomes following PROM. We retrospectively evaluated the maternal and neonatal outcomes and the associated risk factors for 200 consecutive singleton pregnancy outcomes by PROM. Our results suggest that the mean age of the study participants was 22.90 ± 3.45 years ranging from 18–40 years. The estimated occurrences of unfavorable maternal and neonatal outcomes were 24.5 and 28.0%, respectively. Fever (67.3%) followed by puerperal sepsis (12.3%), wound infection (6.1%), and postpartum hemorrhage (6.1%) were common maternal outcomes and birth asphyxia (55.4%) followed by neonatal septicemia (25.0%) and convulsion (5.4%) were common neonatal outcomes. C-reactive protein (CRP) was positive among 44.0% of the mothers, and Escherichia coli was the commonest organism isolated in the cervical swab. The positive serum maternal CRP levels with an adjusted odds ratio (AOR) of 3.3 and 4.8 and latency in conducting delivery with an AOR of 1.1 each were the significant independent predictors of the maternal and neonatal morbidities (p <0.05).