Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 12 , ISSUE 5 ( September-October, 2020 ) > List of Articles

CASE REPORT

Pregnancy and Delivery in a Patient with CADASIL: A Case Report

Akhil M Velayudhan, Jyoti R Chandran, Sukumarapillai Jayasree, Rajeshwary Pillay, Vijay Kumar Bindu

Keywords : Notch3, Subcortical inrarcts,Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Citation Information : Velayudhan AM, Chandran JR, Jayasree S, Pillay R, Bindu VK. Pregnancy and Delivery in a Patient with CADASIL: A Case Report. J South Asian Feder Obs Gynae 2020; 12 (5):326-327.

DOI: 10.5005/jp-journals-10006-1818

License: CC BY-NC 4.0

Published Online: 23-03-2021

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominant arteriopathy, caused by mutations in a gene called Notch3 on long arm of chromosome 19. It is very rare in pregnancy. This case report is presented to create awareness regarding investigating patients presenting with such illness for a better perinatal outcome.


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  1. Dieu JH, Veyckemans F. Perioperative management of a CADASIL type arteriopathy patient. Br J Anaesth 2003;91(3):442–444. DOI: 10.1093/bja/aeg182.
  2. Joutel A, Favrole P, Labauge P, et al. Skin biopsy immunostaining with a Notch3 monoclonal antibody for CADASIL diagnosis. Lancet 2001;358(9298):2049–2051. DOI: 10.1016/S0140-6736(01) 07142-2.
  3. Donnini I, Rinnoci V, Nannucci S, et al. Pregnancy in CADASIL. Acta Neurol Scand 2017;136(6):668–671. DOI: 10.1111/ane.12784.
  4. Roine S, Poyhonen M, Timonen S, et al. Neurologic symptoms are common during gestation and puerperium in CADASIL. Neurology 2005;64(8):1441–1443. DOI: 10.1212/01.WNL.0000158655.71323.8A.
  5. Upadhyay R, Chansoria M, Mahobia M, et al. Headache, primary headaches and their treatment. JSAFOG 2017;3(2):99–104.
  6. Elliott D, Li X, Zhu P, et al. Neurological disorders and pregnancy. 2010;2:13–54.
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