Journal of South Asian Federation of Obstetrics and Gynaecology

Register      Login

VOLUME 12 , ISSUE 5 ( September-October, 2020 ) > List of Articles


Prediction of Preterm Birth on the Basis of Complete Blood Count Parameters

Fareha Khatoon, Hemprabha Gupta, Parul Sinha, Kshama Tiwari, Amrita Singh

Keywords : Neutrophils, Preterm labor,Lymphocytes

Citation Information : Khatoon F, Gupta H, Sinha P, Tiwari K, Singh A. Prediction of Preterm Birth on the Basis of Complete Blood Count Parameters. J South Asian Feder Obs Gynae 2020; 12 (5):288-290.

DOI: 10.5005/jp-journals-10006-1820

License: CC BY-NC 4.0

Published Online: 23-03-2021

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Objective: Preterm labor (PL) is the onset of labor pains before 37 weeks and it eventually leads to preterm birth. Preterm birth accounts for 75% of perinatal mortality and more than half the long-term morbidity.1 Various studies have been done on the ratios of blood cell subtypes like neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) to find out if they can be used as a predictor for diseases in which chronic low-grade inflammation is involved. Inflammation is one of the components in the initiation of PL, so markers of inflammation can be used as a potential predictor of PL. We aimed to study if any association exists between PL and the various blood cell subtypes like NLR, LMR, and PLR in a group of women who were hospitalized with the diagnosis of PL. Materials and methods: A total of 80 pregnant women were enrolled in the study. Forty cases who were admitted in the maternity ward with the diagnosis of PL and 40 gestational age-matched controls who came for routine antenatal care. The cases were further followed and divided into two groups according to gestational age at which they delivered, i.e., pregnant with PL who delivered <37 weeks and pregnant with PL who delivered at ≥37 weeks. The sociodemographic profile and the biochemical parameters of all the groups were compared. Results: The study showed that the neutrophils were significantly elevated in pregnant women with PL and lymphocytes reduced. However, the ratios like NLR, LMR, and PLR were not found to be significantly raised in pregnant women with PL when compared with control. Conclusion: Although we found a significant elevation of neutrophils and a significant reduction of lymphocytes in our study but to use these blood count parameters as a predictor of PL needs more validation. Further measurement of the ratio of subtypes of blood cells like NLR, LMR, and PLR was comparable in both cases and controls.

PDF Share
  1. Goldenberg RL, Culhane JF, Iams JD, et al. Epidemiology and causes of preterm birth. Lancet 2008;371(9606):75–84. DOI: 10.1016/S0140-6736(08)60074-4.
  2. Romero R, Espinoza J, Goncalves LF, et al. Inflammation in preterm and term labor and delivery. Semin Fetal Neonatal Med 2006;11(5):317–326. DOI: 10.1016/j.siny.2006.05.001.
  3. Henderson JJ, Mcwilliam OA, Newnham JP, et al. Preterm birth aetiology 2004-2008. Maternal factors associated with three phenotypes: spontaneous preterm labour, preterm pre-labour rupture of membranes and medically indicated preterm birth. J Matern Fetal Neonatal Med 2012;25(6):642–647. DOI: 10.3109/14767058.2011.597899.
  4. Fergusan KK, Mcelrath TF, Chen YH, et al. Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth. Am J Obstet Gynecol 2015;212(2):e1–e8. DOI: 10.1016/j.ajog.2014.08.007.
  5. Daglar HK, Kirbas A, Kaya B, et al. The value of complete blood count parameters in predicting preterm delivery. Eur Rev Med Pharmacol Sci 2016;20(5):801–805.
  6. Melissa CL, Aaron HG, Jonathan HBS, et al. Neutrophil to lymphocyte ratio and red cell distribution width levelsin preterm vs term births. J Mol Genet Med 2018;12(1):317. DOI: 10.4172/1747-0862.1000317.
  7. Yuan M, Jordan F, Mcinnes IB, et al. Leukocytes are primed in peripheral blood for activation during term and preterm labour. Mol Hum Reprod 2009;15(11):713–724. DOI: 10.1093/molehr/gap054.
  8. Pawelczyk E, Nowicki BJ, Izban MG, et al. Spontaneous preterm labor is associated with an increase in the proinflammatory signal transducer TLR4 receptor on maternal blood monocytes. BMC Pregnancy Childbirth 2010;10:66. DOI: 10.1186/1471-2393-10-66.
  9. Gazer C, Ekin A, Solmaz U, et al. Identification of preterm birth in women with threatened preterm labour between 34 and 37 weeks of gestation. J Obstet Gynaecol 2018;38(5):652–657. DOI: 10.1080/01443615.2017.1399990.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.