Journal of South Asian Federation of Obstetrics and Gynaecology

Register      Login

VOLUME 12 , ISSUE 1 ( January-February, 2020 ) > List of Articles

Drug Review Prospective Self-Control Study

Dehydroepiandrosterone: Is it a Magic Drug?

Shally Gupta

Citation Information : Gupta S. Dehydroepiandrosterone: Is it a Magic Drug?. J South Asian Feder Obs Gynae 2020; 12 (1):59-61.

DOI: 10.5005/jp-journals-10006-1748

License: CC BY-NC 4.0

Published Online: 03-11-2020

Copyright Statement:  Copyright © 2020; The Author(s).


With infertility populations in the developed world rapidly aging, treatment of diminished ovarian reserve (DOR) assumes increasing clinical importance. In developing countries like India, many patients due to economic and cultural restraints are not able to afford ovum donation or other assisted reproductive techniques. Thus, the possibility of a significant improvement in ovarian response with such an intervention in cases of DOR seems to be very promising. Our findings show only an improvement in anti-mullerian hormone (AMH) levels and antral follicle count in women with poor ovarian reserve, which was statistically significant. But we need a bigger sampling size.

  1. Haning RV Jr, Hackett RJ, Flood CA, et al. Plasma dehydroepiandrosterone sulfate serves as a prehormone for 48% of follicular fluid testosterone during treatment with menotropins. J Clin Endocrinol Metab 1993;76(5):1301–1307. DOI: 10.1210/jcem.76.5.8496321.
  2. Barad D, Gleicher N. Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Hum Reprod 2006;21(11):2845–2849. DOI: 10.1093/humrep/del254.
  3. Casson PR, Lindsay MS, Pisarska MD, et al. Dehydroepiandrosterone supplementation augments ovarian stimulation in poor responders: a case series. Hum Reprod 2000;15(10):2129–2132. DOI: 10.1093/humrep/15.10.2129.
  4. Barad DH, Gleicher N. Increased oocyte production after treatment with dehydroepiandrosterone. Fertil Steril 2005;84(3):756. DOI: 10.1016/j.fertnstert.2005.02.049.
  5. Zhang J, Qiu X, Gui Y, et al. Dehydroepiandrosterone improves the ovarian reserve of women with diminished ovarian reserve and is a potential regulator of the immune response in the ovaries. Biosci Trends 2015;9(6):350–359. DOI: 10.5582/bst.2015. 01154.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.