Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 10 , ISSUE 1 ( January-March, 2018 ) > List of Articles


A Prospective Study to evaluate Pregnancy Outcomes in Patients with Systemic Lupus Erythematosus

Alakendu Ghosh, Sweta Tiwari, Subhash C Biswas, Mriganka M Saha

Keywords : Adverse outcomes, Pregnancy, Systemic lupus erythematosus

Citation Information : Ghosh A, Tiwari S, Biswas SC, Saha MM. A Prospective Study to evaluate Pregnancy Outcomes in Patients with Systemic Lupus Erythematosus. J South Asian Feder Obs Gynae 2018; 10 (1):45-48.

DOI: 10.5005/jp-journals-10006-1556

Published Online: 01-12-2018

Copyright Statement:  Copyright © 2018; The Author(s).


Aim: Study of systemic lupus erythematosus (SLE) with pregnancy to manage them in a multidisciplinary approach for better pregnancy outcomes. Materials and methods: This study was a prospective cohort study. A total of 100 pregnant women with diagnosed SLE were included in the study and another 100 age-matched normal pregnant women without any obvious complications were recruited as controls. Results: Maternal organ involvement—five patients of renal involvement and seven patients of cardiac and pulmonary involvement in SLE group—was found. Antinuclear antibody (ANA) was positive in all cases and 87 were positive for antidouble- stranded deoxyribonucleic acid (anti-dsDNA) antibody. The disease flare was found only in a single case of planned pregnancy and total nine cases of unplanned pregnancy. Most of the women, 41 (53.25%), in the SLE group were delivered by cesarean section, but only 24 (25%) in the control group underwent cesarean section. Conclusion: The SLE with pregnancy is a high-risk condition where prepregnancy disease-free interval is the most important criteria to minimize complications. Hydroxychloroquine can be used safely throughout the pregnancy. Multidisciplinary approach plays a crucial part in management. Clinical significance: Management of lupus flares and preeclampsia during SLE pregnancy is being treated with difficulties with overlapping clinical features. Presence of antiphospholipid antibodies (APLA) is a major unresolved issue. Adverse events to maternal and fetal well-being with use of appropriate medications are required for optimum outcomes.

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