Citation Information :
Nambiar J, Pai MV, Amruta C. A Simple Method of Assessing Fetal Lung Maturity by Lamellar Body Concentration in Amniotic Fluid. J South Asian Feder Obs Gynae 2018; 10 (4S2):409-412.
Objective: To find out whether amniotic fluid lamellar body concentrations (LBC) can predict neonatal respiratory distress syndrome (RDS)
Materials and methods: Amniotic fluid was obtained at the time of cesarean section was sent to the laboratory for lamellar body concentrations in amniotic fluid. The lamellar body concentrations were analyzed and correlated with the incidence of RDS.
Results: The incidence of RDS at different gestational age with an LBC cut off of 41,500 was studied. Among 220 patients studied, Respiratory distress was seen in 53 (24.09%) of patients. There is a significant correlation between decreasing lamellar body count in preterms and incidence of RDS. LBC count has a sensitivity of 92.7 %, the specificity of 90 %, a positive-predictive value of 73% and a negative-predictive value of 98% in predicting respiratory distress syndrome.
Conclusion: LBC count in the current study is a cheap, easy and reliable method of assessing fetal lung maturity.
Abbreviations: RDS: Respiratory distress syndrome; LBC: Lamellar body count; FLM: Fetal lung maturity.
Ethics approval: Ethical committee clearance was obtained on 15/9/2011 before the start of the study from Manipal University ethical committee and Kasturba Hospital, Manipal under reference number IEC248/2011.
Angus D, Linde-Zwirble W, et al. Epidemiology of neonatal respiratory failure in the United States: Projections from California and New York. Am J Respir Crit Care Med 2001;164:1154-1160.
Fakhoury G, Daikoku NH, et al. Lamellar body concentrations and the prediction of fetal pulmonary maturity. Am J Obstet Gynecol 1994;170:72-76.
Khazardoost S, Yahyazadeh H, et al. Amniotic fluid lamellar body count and its sensitivity and specificity in evaluating of fetal lung maturity: J Obstet Gynaecol 2005;25(3):257-259.
Ross GE, Frank N, et al. Decreased laboratory testing for lecithin-to-sphingomyelin ratio and phosphatidylglycerol after fetal lung maturity assessment from lamellar body count in amniotic fluid. JAOA 2002;102:8-14.
Roiz-Hernández J, Navarro-Solis E, et al. Lamellar bodies as a diagnostic test of fetal lung maturity. International Journal of Gynecology & Obstetrics 2002;77(3):217-221.
Haymond S, Luzzi VI, et al. A direct comparison between lamellar body counts and fluorescent polarization methods for predicting respiratory distress syndrome. Am J Clin Pathol 2006;126:894-899.
Štimac T, Petrović O, et al. Lamellar body count as a diagnostic test in predicting neonatal respiratory distress syndrome. Croat Med J 2012;53:234-238
KafkaslıA, Türkçüoğlu I, et al. Good glycemic control does not alter lamellar body count in pregnancies complicated with diabetes mellitus. Perinatoloji Dergisi 2011;19(2): 113-114.
Besnard AE, Soetinah AM, et al. Mol Lecithin/sphingomyelin ratio and lamellar body count for fetal lung maturity: a meta-analysis. European Journal of Obstetrics & Gynecology and Reproductive Biology 2013;169:177-183.
Tsuda H, Takahashi Y, et al. Intra-amniotic infection increases amniotic lamellar body count before 34 weeks of gestation. J Matern Fetal Neonatal Med 2010;23:1230-1236.
