Prediction of Pregnancy-induced Hypertension by Maternal Serum Beta Human Chorionic Gonadotropin Levels in Early Second Trimester of Pregnancy
Anuja V Bhalerao, Sanyukta S Dawle
Keywords :
Beta human chorionic gonadotropin, Preeclampsia, Pregnancy-induced hypertension
Citation Information :
Bhalerao AV, Dawle SS. Prediction of Pregnancy-induced Hypertension by Maternal Serum Beta Human Chorionic Gonadotropin Levels in Early Second Trimester of Pregnancy. J South Asian Feder Obs Gynae 2018; 10 (2):104-109.
Objective: The study aims at testing the hypothesis that women with high serum beta human chorionic gonadotropin (β-hCG) in early second trimester have risk of developing pregnancy-induced hypertension and poor maternal and neonatal outcome. Early identification of at-risk women may help in taking timely preventive and curative management to prevent or delay complications associated with pregnancy-induced hypertension.
Materials and methods: Serum β-hCG was done in 400 antenatal women between 12 and 24 weeks of gestation and they were followed up till delivery and postpartum for 7 days. Assessment of serum β-hCG and its predictability for development of pregnancy-induced hypertension and its effect on maternal and fetal outcome were done.
Results: Women with high serum β-hCG levels at 12 to 24 weeks of gestation have 1.67 times more risk of developing pregnancy-induced hypertension (p = 0.035) and poor maternal and perinatal outcome.
Conclusion: Elevated maternal serum β-hCG at early second trimester is a good noninvasive predictor of pregnancy-induced hypertension. The maternal and perinatal outcome was directly proportional to levels of serum β-hCG.
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