Journal of South Asian Federation of Obstetrics and Gynaecology

Register      Login

VOLUME 9 , ISSUE 3 ( July-September, 2017 ) > List of Articles


Müllerian Anomalies: A Cause for Primary Amenorrhea

Anuja V Bhalerao, Richa Garg

Citation Information : Bhalerao AV, Garg R. Müllerian Anomalies: A Cause for Primary Amenorrhea. J South Asian Feder Obs Gynae 2017; 9 (3):221-224.

DOI: 10.5005/jp-journals-10006-1499

License: CC BY 3.0

Published Online: 01-12-2012

Copyright Statement:  Copyright © 2017; The Author(s).



Primary amenorrhea is a challenging entity as it affects the reproductive outcome. Primary amenorrhea is an absence of secondary sexual characters until 14 years of age or absence of menstruation with secondary sexual characters until 16 years of age.


The aim of this article is to study the frequency, etiologic causes, presentation, diagnosis, and optimal mode of management of primary amenorrhea.

Materials and methods

All girls who had not attained menarche until 16 years of age in the absence of secondary sexual characters and until 14 years, if no secondary sexual characters, and were willing for follow-up were subjected to investigations and were treated as per the etiology.


Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome was the most common cause of primary amenorrhea (42.85%) followed by imperforate hymen (28.57%) and transverse vaginal septum (21.42%), one each of low, mid, and high varieties. There was one case of androgen insensitivity syndrome.


Establishing correct diagnosis is essential for planning treatment and management strategies in primary amenorrhea as treatment goals are preservation of fertility and progression of normal development.

How to cite this article

Bhalerao AV, Garg R. Müllerian Anomalies: A Cause for Primary Amenorrhea. J South Asian Feder Obst Gynae 2017;9(3):221-224.

  1. Clinical gynecologic endocrinology and infertility. Lippincott, Williams & Wilkins; 2005. p. 403ff.
  2. Amenorrhea evaluation of patient. Am Fam Physician 2006 Apr 15;73(8):1374-1382.
  3. Available from:
  4. Causes of primary amenorrhea: a report of 295 cases in Thailand. J Obstet Gynaecol Res 2012 Jan;38(1):297-301.
  5. Mullein anomalies – a cause of primary amenorrhoea. Int J Reprod Contracept Obstet Gynecol 2013 Sep;2(3):393-397.
  6. Delayed puberty: an updated study of 326 patients. Trans Gynecol Obstet Soc 1989;8:146-162.
  7. Obstructive Müllerian anomalies: Case report, diagnosis, and management. Am J Obstet Gynecol. 2001 Aug;185(2):338-344.
  8. Management of hematocolpos in adolescents with transverse vaginal septum. Arch Gynecol Obstet. 2012 Apr;285(4):1083-1087.
  9. The Mayer-Rokitansky-Küster-Hauser syndrome (congenital absence of uterus and vagina) – phenotypic manifestations and genetic approaches. J Negat Results Biomed 2006 Jan 27;5:1.
  10. Obstructive anomalies of the female reproductive tract. J Reprod Med 1999 Mar;44(3):233-240.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.