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VOLUME 16 , ISSUE S2 ( August, 2024 ) > List of Articles

REVIEW ARTICLE

Elucidating the Relationship between Single-nucleotide Polymorphisms and Impaired Fertility

Shreya Nautiyal, Girish Sharma, M Gouri Devi

Keywords : Infertility, In vitro fertilization, Single-nucleotide polymorphism

Citation Information :

DOI: 10.5005/jp-journals-10006-2479

License: CC BY-NC 4.0

Published Online: 02-09-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

Infertility is a prevalent health issue which affects ~15–20% of couples worldwide. Almost one-half of idiopathic infertility cases have been accepted to be caused by genetic basis, yet the basic causes are obscure. The reason for the present review is to comprehend and acquire information on the current status of examination on the genetics of females and its relationship with infertility. This article reviews the effects of single-nucleotide polymorphisms (SNPs) present in follicle-stimulating hormone receptor (FSHR), luteinizing hormone/choriogonadotropin receptor (LHCGR), luteinizing hormone subunit beta (LHβ), anti-Mullerian hormone receptor (AMHR), and estrogen receptor (ESR) on female infertility. To investigate the strength of the relationship between SNPs and infertility, 74 articles were studied from multiple sources such as PubMed, Medline, and Google Scholar. Further more, a conclusion can be drawn that SNPs do have an impact on infertility irrespective of ethnicity and more research needs to be done in this area to understand the correlation of polymorphisms and infertility in order to benefit the population affected by it.

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