Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 16 , ISSUE S1 ( April, 2024 ) > List of Articles

CASE REPORT

Xanthogranulomatous Salpingo-oophoritis with Incidental Pheochromocytoma: A Unique Combination Identified in Two Cases

Archana Chirag Buch, Mangesh Londhe, Reshma Alexander, Sargam Dhaliwal

Keywords : Case report, Oophoritis, Pheochromocytoma, Salpingitis, Xanthogranulomatous

Citation Information :

DOI: 10.5005/jp-journals-10006-2374

License: CC BY-NC 4.0

Published Online: 06-03-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

Lipid-rich foamy macrophages intermingled with lymphocytes, plasma cells, neutrophils, and eosinophils are the hallmark of xanthogranulomatous inflammation. Due to its capacity for mass formation and destructiveness, it is an uncommon entity that mimics neoplasm. Rarely, it is detected in the female genital system; however, it is most frequently seen in the kidney and gallbladder. It is associated with endometriosis, uterine leiomyoma, ovarian hemangioma, and can occur secondary to diverticulitis, chronic bacterial infections, ineffective antibiotic treatment, and uterine artery embolization. The annual incidence of pheochromocytoma is 0.8 per 100,000 person-years and it is a catecholamine-secreting tumor that arises from chromaffin cells in the adrenal medulla. Synchronous presentation of xanthogranulomatous salpingo-oophoritis (XSO) with pheochromocytoma has not been described so far. Hence, we report a series of two such cases mimicking malignancy and have discussed the pathogenesis of the above association.


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  1. Zhang XS, Dong HY, Zhang LL, et al. Xanthogranulomatous inflammation of the female genital tract: Report of three cases. J Cancer 2012;3:100–106. DOI: 10.7150/jca.3929.
  2. Portela Carvalho A, Costa Braga A, Ferreira H. Case report: Xanthogranulomatous salpingo-oophoritis associated to endometriosis—are these different histologic expressions of the same disease? F1000Research 2020;9:94. Available from: https://doi.org/10.12688/f1000research.22206.1.
  3. Spiro A, Usman A, Ajmal A, et al. Asymptomatic and biochemically silent pheochromocytoma with characteristic findings on imaging. Case Rep Endocrinol 2020;2020:8847261. DOI: 10.1155/2020/8847261.
  4. Gray Y, Libbey NP. Xanthogranulomatous salpingitis and oophoritis: A case report and review of the literature. Arch Pathol Lab Med 2001;125(2):260–263. DOI: 10.5858/2001-125-0260- XSAO.
  5. Jayashree N, Shobha K, Bafna UD. Xanthogranulomatous oophoritis: A diagnostic dilemma. J Obstet Gynaecol India 2019;69:44–47. DOI: 10.1007/s13224-017-0967-6.
  6. Tanwar H, Joshi A, Wagaskar V, et al. Xanthogranulomatous salpingooophoritis: The youngest documented case report. Case Rep Obstet Gynecol 2015;2015:237250. DOI: 10.1155/2015/237250.
  7. Rathore R, Chauhan S, Suman M, et al. Xantogranulomatous salpingo-oophoritis, lessons learnt: Report of two cases with unusual presentation. J Fam Reprod Health 2017;11(3):174–178. PMID: 30018655.
  8. Pang SY, Aggarwal IM, Lim YK. Xanthogranulomatous salpingo–oophoritis mimicking an ovarian malignancy – A series of 3 cases and review of literature. Obstet Gynecol Int J 2016;5(3):348–351. DOI: 10.15406/ogij.2016.05.00162.
  9. Arnold DT, Reed JB, Burt K. Evaluation and management of the incidental adrenal mass. Proc (Bayl Univ Med Cent) 2003;16(1):7–12. DOI: 10.1080/08998280.2003.11927882.
  10. Grasso S, Michaels GD, Kinsell LW. Effects of norepinephrine upon lipid metabolism in a patient with biliary cirrhosis. Metabolism 1964;13:1133–1141. DOI: 10.1016/0026-0495(64)90153-2.
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