Keywords :
Abortion, Medical termination of pregnancy, Misoprostol, Prostaglandin
Citation Information :
Roy P, Nadkarni A, Sahoo LN, Singh K, Garg R. Oral vs Vaginal Misoprostol for Medical Termination of Pregnancy. J South Asian Feder Obs Gynae 2024; 16 (5):476-478.
Background: Considering the different available results on the effectiveness of various doses of misoprostol and methods of administration. The aim of this study was to compare oral and vaginal misoprostol for medical termination of pregnancy (MTP).
Materials and methods: This randomized clinical trial study was performed on 140 pregnant women, who wanted MTP. Pregnant women were divided randomly into two groups – oral and vaginal misoprostol groups by simple sampling. Misoprostol 400 μg was given to both groups every 4 hours up to five times. The effectiveness of misoprostol (the excretion of gestation products) and its side effects (bleeding, fever, etc.) were studied in two groups. The data collection instrument was a questionnaire. Data were analyzed using SPSS (version 22 software).
Results: The results showed that there were no statistically significant differences between the oral (82.3%) and vaginal (80%) misoprostol groups in terms of response to treatment. Although in our study, the need for curettage was higher in the vaginal group (42.8) than in the oral group (34.3), the difference was not statistically significant. The intervals between consuming oral misoprostol pills and the excretion of gestation products in the oral and vaginal groups were 4.09 ± 1.56 and 3.67 ± 1.4 hours, respectively. In terms of complications, only two cases of oral misoprostol group experienced complications.
Conclusion: Although the risk of complications in the oral method and the need for curettage in vaginal group is high, the effectiveness of oral and vaginal misoprostol for MTP is similar.
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