Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 16 , ISSUE 4 ( July-August, 2024 ) > List of Articles

Original Article

Quadruple Test Can Predict Hypertension in Pregnancy: The Excellent Center Hospital-based Study

Watcharin Chirdchim, Mutita Ngamlamai, Rujira Manorompattarasarn

Keywords : Beta-hCG, Prediction, Pregnancy-induced hypertension, Quadruple test

Citation Information : Chirdchim W, Ngamlamai M, Manorompattarasarn R. Quadruple Test Can Predict Hypertension in Pregnancy: The Excellent Center Hospital-based Study. J South Asian Feder Obs Gynae 2024; 16 (4):388-392.

DOI: 10.5005/jp-journals-10006-2455

License: CC BY-NC 4.0

Published Online: 09-07-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

Aims and background: To evaluate biomarkers in the quadruple test that can predict hypertension in pregnancy and other adverse pregnancy outcomes. Materials and methods: Retrospective data collection from medical records of anonymous pregnant women above 18 years old who had attended antenatal care at Phrapokklao Hospital, performed the quadruple test, and delivered at Phrapokklao Hospital in the period July 2020–March 2022. The exclusion criteria were fetal chromosome anomaly and maternal diabetes mellitus. The biomarkers in the quadruple test of participants were calculated and compared to whether they were related to pregnancy-induced hypertension or other adverse pregnancy outcomes. Results: Gestational hypertension correlated to high-risk quadruple test, age, multiparity, and BMI. The area under the ROC curve between beta-hCG and gestational hypertension was (AUC) 0.692. We found that beta-hCG of 2.86 MoM was the mean of beta-hCG in participants who had hypertension. Other adverse pregnancy outcomes weren't correlated with quadruple test results. Conclusion: Age, BMI, parity, and high-risk quadruple test were associated with gestational hypertension. Nevertheless, only beta-hCG could be assisted in predicting gestational hypertension and preeclampsia. Clinical significance: Clinicians should be careful about gestational hypertension in high-risk quadruple test pregnancy.


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