Journal of South Asian Federation of Obstetrics and Gynaecology

Register      Login

VOLUME 16 , ISSUE 3 ( May-June, 2024 ) > List of Articles

CASE REPORT

A Rare Case of Management of Pemphigus Vulgaris in Pregnancy and Newborn

Yash Bahuguna, Asmita Patil, Bhavna Trivedi

Keywords : Antenatal care, Bad obstetrics history, Case report, Fetomaternal outcomes, High risk pregnancy, Neonatal pemphigus, Pemphigus vulgaris, Pregnancy

Citation Information : Bahuguna Y, Patil A, Trivedi B. A Rare Case of Management of Pemphigus Vulgaris in Pregnancy and Newborn. J South Asian Feder Obs Gynae 2024; 16 (3):319-321.

DOI: 10.5005/jp-journals-10006-2415

License: CC BY-NC 4.0

Published Online: 29-04-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

Pemphigus vulgaris (PV) is a rare autoimmune disorder that causes flaccid vesiculobullous lesions and erosions on the skin, with an annual incidence of 0.09–1.8% in India. Its occurrence during pregnancy is even rarer, with only 47 cases reported in the literature over a 49 years. The condition can worsen during the first and second trimesters and postpartum, with a phase of waning during the third trimester, which may be associated with endogenous corticosteroid secretion. The condition can affect various parts of the body, including pressure points, skin-to-skin contact areas, and oral and nasal mucosae. It can also lead to a transient benign form of neonatal lesions called pemphigus neonatorum due to transplacental transmission. Complications such as infertility and stillbirth can occur in women suffering from PV. This is a case of ART with IVF conception and managed successfully by our hospital, it was well-controlled with oral steroids and had an uneventful course in pregnancy, transient neonatal lesions also appeared after birth, which were managed successfully. Exacerbation postpartum was also seen but occurred due to non-compliance with corticosteroid therapy by the patient.


PDF Share
  1. Langan SM, Smeeth L, Hubbard R, et al. Bullous pemphigoid and pemphigus vulgaris—incidence and mortality in the UK: Population-based cohort study. BMJ 2008;337(7662):a180. DOI: 10.1136/bmj. a180.
  2. Kanwar AJ, De D. Pemphigus in India. Indian J Dermatol Venereol Leprol 2011;77(4):439–449. DOI: 10.4103/0378-6323.82396.
  3. Lin L, Zeng X, Chen Q. Pemphigus and pregnancy. Saudi Med J 2015;36(9):1033–1038. DOI: 10.15537/smj.2015.9.12270.
  4. Kardos M, Levine D, Gürcan HM, et al. Pemphigus vulgaris in pregnancy: Analysis of current data on the management and outcomes. Obstet Gynecol Surv 2009;64(11):739–749. DOI: 10.1097/OGX.0b013e3181bea089.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.