Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 16 , ISSUE 3 ( May-June, 2024 ) > List of Articles

REVIEW ARTICLE

Nurturing the Mind from Within: Exploring the Role of Gut–Microbiota–Brain Axis in Postpartum Depression

Srinidhi Rai, Priya Alva, Sriram Naresh

Keywords : Postpartum depression, Psychology, Screening

Citation Information : Rai S, Alva P, Naresh S. Nurturing the Mind from Within: Exploring the Role of Gut–Microbiota–Brain Axis in Postpartum Depression. J South Asian Feder Obs Gynae 2024; 16 (3):285-288.

DOI: 10.5005/jp-journals-10006-2411

License: CC BY-NC 4.0

Published Online: 29-04-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

The pathophysiology of postpartum depression (PPD) mostly involves disruptions of the immunological system, gut microbiota, neurotransmitters, hormone production, and neuroendocrine regulation. This review explores the reciprocal exchange of signals along the gut–brain axis, with a particular emphasis on the role that gut microorganisms play in neurotransmitter synthesis, precursor generation, and the secretion of vital metabolites, thus unravelling the complex interactions of the microbiota–gut–brain axis to pave a better understanding of microbiota-mediated pathogenesis, avenues for therapeutic possibilities leveraging microbiota–gut–brain axis modulations.


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