Background: In Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome goal of treatment is to create a sexually functioning neovagina. There are various options available, but the search for the ideal one is still on. The use of dental impression compound for mold covered with skin graft is new. Its mention in literature is very uncommon. Aim: Vaginoplasty using impression compound used by dentists covered by skin graft is being reported to assess anatomical and functional outcomes and to showcase the evolution of vaginoplasty. Case description: A 22-year-old woman with primary amenorrhea due to MRKH syndrome, about to get married in 4 months, underwent vaginoplasty using a dental impression compound covered with a skin graft. The anatomical and functional outcome was satisfying in this woman. On day 8, of vaginoplasty, the length of the vagina formed was 9.4 cm. The vaginal width was three fingers breadth. The functional outcome in relation to sexual satisfaction was good after 1 year of follow-up. Conclusion: Dental impression compound mold with skin graft is an alternative in vaginal genesis as it is cheap and easily available. Proper patient selection, counseling regarding self-replacement, and psychological support are key to the success of vaginoplasty. Clinical significance: The surgical development of a neovagina in MRKH syndrome has been attempted for a long time, with varying degrees of success. So the search for an ideal method is still on.