Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 15 , ISSUE 6 ( November-December, 2023 ) > List of Articles


β-HCG and PAAP-A Levels during First Trimester as a Predictor of Gestational Hypertension and Growth-restricted Fetus

Rahul Bhagchand Chavan, Yogesh Gadekar, Vaibhav Khairnar, Meenakshi Pawar

Keywords : β-human chorionic gonadotropin, First trimester, Gestational hypertension, Pregnancy-associated plasma protein-A, Preeclampsia, Pregnancy complications

Citation Information : Chavan RB, Gadekar Y, Khairnar V, Pawar M. β-HCG and PAAP-A Levels during First Trimester as a Predictor of Gestational Hypertension and Growth-restricted Fetus. J South Asian Feder Obs Gynae 2023; 15 (6):737-741.

DOI: 10.5005/jp-journals-10006-2366

License: CC BY-NC 4.0

Published Online: 04-12-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Objective: The aim of this study is to study the association between abnormal serum analytes [pregnancy-associated plasma protein-A and β-human chorionic gonadotropin (β-HCG)] and the development of gestational hypertension (HTN) and intrauterine growth restriction (IUGR). Methods: A prospective observational study was carried out at ANC clinic of a hospital over a period of 18 months starting from January 2021 to June 2022. The ethical clearance was obtained from ethics committee of the institute. A total of 150 singleton pregnant women registered in the first trimester between 11 and 13.6 weeks were included in the study. The anthropometric measurements like height and weight were recorded and body mass index (BMI) was calculated. Results: Out of 17 subjects with low β-HCG, 2 (11.8%) developed gestational HTN, 2 (11.8%) developed IUGR, 2 (11.8%) developed both gestational HTN and IUGR, and 11 (64.7%) had no complications. Among subjects with normal β-HCG, 13 (10.3%) developed gestational HTN, 4 (3.2%) developed IUGR, 6 (4.8%) developed both gestational HTN and IUGR, and 103 (81.7%) had no complications. Among seven subjects with high βHCG level, two (28.6%) developed gestational HTN, two developed both gestational HTN and IUGR, and three (4.9%) had no complications. The result of Chi-square test indicated a significant association of gestational HTN and IUGR with the level of β-HCG (p < 0.05). Conclusion: The levels of β-HCG and PAAP-A during first trimester are significantly associated with the obstetric complications. Hence, in along with the routine check-ups and screenings, the levels of β-HCG and PAAP-A during first trimester might improve the chances of early identification of development of gestational HTN and IUGR.

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