Intrahepatic cholestasis, Liver disease in pregnancy, Progesterone
Citation Information :
Ranjan K, Soumyashree T, Nair P, Prasad M, Mounika MS. Progesterone Support as a Cause for Early Intrahepatic Cholestasis of Pregnancy: A Case Series. J South Asian Feder Obs Gynae 2023; 15 (5):627-628.
Progesterone is extensively used in pregnancy support and the increasing incidence of high-risk pregnancy may need further extensive progesterone usage. While intrahepatic cholestasis of pregnancy (IHCP) is primarily a third trimester problem, few cases of early onset IHCP are documented. In this context, a series of three cases of IHCP among pregnant patients who used progesterone is described. Mechanisms of this otherwise rare occurrence are discussed. Association between progesterone use and early onset IHCP merits further study.
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