To Study the Average Possible Low Dose of Magnesium Sulfate to Control the Convulsions in Eclampsia in a Tertiary Care Hospital

Varsha Narayana Bhat; Shamrao Ramji Wakode; Kiran Ambatwar

doi:10.5005/jp-journals-10006-2302

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To Study the Average Possible Low Dose of Magnesium Sulfate to Control the Convulsions in Eclampsia in a Tertiary Care Hospital

Varsha Narayana Bhat, Shamrao Ramji Wakode, Kiran Ambatwar

Keywords : Birth weight, Cesarean, Comorbidities, Eclampsia, Maternal and fetal outcome, Preeclampsia

Citation Information : Bhat VN, Wakode SR, Ambatwar K. To Study the Average Possible Low Dose of Magnesium Sulfate to Control the Convulsions in Eclampsia in a Tertiary Care Hospital. J South Asian Feder Obs Gynae 2023; 15 (5):560-563.

DOI: 10.5005/jp-journals-10006-2302

License: CC BY-NC 4.0

Published Online: 31-10-2023

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Abstract

Objective: The aim of this study is to evaluate the efficacy of minimal effective dose of magnesium sulfate (MgSO₄) for control of convulsions in eclampsia and also at reducing the MgSO₄-related toxicity thus by reducing the dose of MgSO₄ and also to analyze the maternal and perinatal outcomes among these patients. Design: The prospective observational study was carried out between January 2019 and January 2022 at Dr. Shankarrao Chavan Govt Medical College and Hospital, Nanded, Maharashtra. Setting: Tertiary care hospital, Nanded, Maharashtra. Materials and methods: Injection of MgSO₄ 14 gm loading dose was given at the admission in eclampsia cases, and further doses of MgSO₄ were given with close monitoring of patients and a reduction in the number of doses of MgSO₄ doses was done as per the patient's condition. If the patient gets the next episode of convulsion, immediately 2 gm IV MgSO₄ drip was given. Results: In our study, out of 200 patients, 2.5% of them had received only a loading dose of MgSO₄, whereas maximum (61.5%) of them had received 20–24 gm of MgSO₄. During the observation period of 5–7 days post delivery, none of the patients had any complications like repeat convulsions, loss of consciousness, or intracranial hemorrhage, even after reducing the possible doses of MgSO₄. The recurrence rate of convulsions is 7%. Total MgSO₄ doses were administered (in grams) with a mean of 24.83 gm among the study population. There was no significant correlation between doses of MgSO₄ received, and the number of convulsions reoccurred with p-value > 0.05. Conclusion: It appears that treatment of eclampsia cases should be individualized by considering the level of consciousness, laboratory parameters, induction delivery interval, convulsion to delivery interval, number of convulsions, and hence deciding further maintenance doses to be given or omitted. Due to the low toxicity profile, reduced monitoring, cost-effectiveness, and equally effective in comparison with the Pritchard regimen, the present regimen is recommended.

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