Journal of South Asian Federation of Obstetrics and Gynaecology

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Volume  16 (2024)
Volume  15 (2023)
Volume  14 (2022)
Volume  13 (2021)
Volume  12 (2020)
Volume  11 (2019)
Volume  10 (2018)
Volume  9 (2017)
Volume  8 (2016)
Volume  7 (2015)
Volume  6 (2014)
Volume  5 (2013)
Volume  4 (2012)
Volume  3 (2011)
Volume  2 (2010)
Volume  1 (2009)
Related articles

VOLUME 15 , ISSUE 4 ( July-August, 2023 ) > List of Articles

REVIEW ARTICLE

Role of Oxygenation Factor Hypoxia-inducible Factor-1α (HIF-1α) as Prognostic Indicators in Cervical Cancer

I Gde Sastra Winata, I Wayan Megadhana, Endang Sri Widiyanti, Aldo Albert Lawu

Keywords : Cervical cancer, Human papillomavirus 16, Hypoxia-inducible factors-1α, Oxygenation factors

Citation Information : Winata IG, Megadhana IW, Widiyanti ES, Lawu AA. Role of Oxygenation Factor Hypoxia-inducible Factor-1α (HIF-1α) as Prognostic Indicators in Cervical Cancer. J South Asian Feder Obs Gynae 2023; 15 (4):490-496.

DOI: 10.5005/jp-journals-10006-2222

License: CC BY-NC 4.0

Published Online: 16-09-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Abstract

Objective: This literature aims to know the role of HIF-1a as a prognostic indicator of oxygenation in cervical cancer. Materials and methods: All references used in this literature review were searched in several databases such as PubMed (Medline), Google Scholar, and ScienceDirect. Results: Hypoxia can cause damage to cell death because the body's cells are very dependent on the oxygen constant supply to function and survive. Hypoxia inducible factor-1α plays an important role in tumor development through the regulation of gene expression (angiogenesis, cell survival, and drug resistance) especially under hypoxemic conditions such as embryogenesis, cardiovascular disease, and carcinogenesis. High HIF-1α expression can cause a decrease in tumor latency, an increase in blood vessel density, tumor volume, and tumor permeability, and promote tumor growth, while a decrease in HIF-1α activity will cause a decrease in growth progression, vascularization, and energy metabolism. Conclusion: The use of gene expression induced by hypoxia as a biomarker for tumor hypoxia has been investigated especially HIF-1α, which regulates tumor cell metabolism and metastasis in hypoxic states. The HIF-1α protein also contributes to more progressive tumor growth and it is possible that this effect is synergistic with the human papillomavirus (HPV) oncogene. Several studies have stated a strong relationship between HIF-1α protein and cancer.

HTML PDF Share
  1. Zhang S, Xu H, Zhang L, et al. Cervical cancer: Epidemiology, risk factors and screening. Chin J Cancer Res 2020;32(6):720–728. DOI: 10.21147/j.issn.1000-9604.
  2. CDC. “HPV-Associated Cancer Statistics”. Accessed March 7, 2022. Available from: https://www.cdc.gov/cancer/hpv/statistics/
  3. Fowler JR, Maani EV, Dunton CJ, et al. Cervical Cancer. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023. PMID: 28613745.
  4. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. DOI: 10.3322/caac.21660.
  5. Kemenkes RI. Penyakit Kanker di Indonesia Berada Pada Urutan 8 di Asia Tenggara dan Urutan 23 di Asia. Diakses tanggal. Accessed November 3, 2021.
  6. Kementerian Kesehatan Republik Indonesia. Infodatin: Stop Kanker. Jakarta Selatan: Pusat Data dan Informasi. 2015.
  7. Oktaviani BD, Sriwidyani NP, Sumadi IWJ. Karakteristik Klinikopatologi Penderita Kanker Serviks Uteri Berdasarkan Data di Laboratorium Patologi Anatomi RSUP Sanglah Denpasar Tahun 2011-2015. Bali, Indonesia: E-Jurnal Udayana Medika 7(8). ISSN: 2303-1395.
  8. Andrijono. Kanker Serviks. 2016. Divisi Onkologi. Departemen Obstetri- Ginekologi. Fakultas Kedokteran Universitas Indonesia. Edisi 5.
  9. Kim Yun Hwan, In-Ae Park, Woong-Yang Park, et al. “Hypoxia-Inducible Factor 1α Polymorphisms and Early-Stage Cervical Cancer.” Int J Gynecol Cancer 2011;21(1):2–7. DOI: 10.1097/IGC.0b013e318204f6e6.
  10. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000;407(6801):249Y257. DOI: 10.1038/35025220.
  11. Xu P, Zhu P, Ou Y, et al. Expression of VEGF and HIF-1alpha; in locally advanced cervical cancer: Potential biomarkers for predicting preoperative radiochemotherapy sensitivity and prognosis. Onco Targets and Ther 2016;9:3031–3037. DOI: 10.2147/OTT.S104142.
  12. Psychotherapy in Terminal Care. (2010). Gynecological Oncology: National Reference Book / Editor, Prof. Dr. dr. M. Farid Aziz, SpOG (K), dr. Andrijono, SpOG (K), Prof. dr. Abdul Bari Saifuddin, SpOG (K). Jakarta: PT. Library Sarwono Prawirohardjo.
  13. Bajoriya R, Makde M, Kamal M. Immunohistochemistry and Tissue Microarray Techniques to Demonstrate Human Papilloma Virus Antigen and Cell Cycle Proteins in Squamous Intraepithelial Lesions and Cancer Cervix. J South Asian Feder Obst Gynae 2020;12(2):116–117. DOI: 10.5005/jp-journals-10006-1780.
  14. Graham, Sheila V. “The human papillomavirus replication cycle, and its links to Cancer progression: A comprehensive review.” Clin Sci (Lond) 2017;131(17):2201–2221. DOI: 10.1042/CS20160786.
  15. Motoyama S, Ladines-Llave CA, Luis Villanueva S, et al. The role of human papilloma virus in the molecular biology of cervical carcinogenesis. Kobe J Med Sci 2004;50(1-2):9–19. PMID: 15342967.
  16. Saraiya U. Current trends in the management of cervical intraepithelial neoplasia. J South Asian Feder Obst Gynae 2022;14(4):458–464. DOI:10.5005/jp-journals-10006-2098.
  17. Kim JI, Choi KU, Lee IS, et al. Expression of hypoxia markers and their prognostic significance in soft tissue sarcoma. Oncol Lett 2015;9(4):1699–1706. DOI: 10.3892/ol.2015.2914.
  18. Rademakers SE, Lok J, van der Kogel, et a. Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1, and MCT4. BMC Cancer 2011:11(1):167. DOI: 10.1186/1471-2407-11-167.
  19. Muz B, de la Puente P, Azab F, et al. The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy. Hypoxia (Auckl) 2015;3:83–92. DOI: 10.2147/HP.S93413.
  20. Kwasiborski, Przemysław Jerzy, Paweł Kowalczyk, et al. “Selected, biochemical markers of hypoxia”. Przegl Lek 2012;69(3):115–119. PMID: 22764653.
  21. SørensenBS, Horsman MR. “Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways.” Front Oncol 2020;10:562. DOI: 10.3389/fonc.2020.00562.
  22. Horsman MR, Mortensen LS, Petersen JB, et al. Imaging hypoxia to improve radiotherapy outcome. Nat Rev Clin Oncol 2012;9:674–687. DOI: 10.1038/nrclinonc.2012.171.
  23. Hara S, Nakashiro K, Klosek SK, et al. “Hypoxia enhances c-Met/HGF receptor expression and signaling by activating protein HIF-1α in human salivary gland cancer cells.” Oral Oncol 2006;42(6):593–598. https://doi.org/10.1016/j.oraloncology.2005.10.016.
  24. Bárdos JI, Ashcroft M. Negative and positive regulation of HIF-1: A complex network. Biochim Biophys Acta 2005;1755(2):107–120. DOI: 10.1016/j.bbcan.2005.05.001.
  25. Chen Q, Tian WJ, Huang ML, et al. Association between HIF-1 alpha gene polymorphisms and response in patients undergoing neoadjuvant chemotherapy for locally advanced cervical cancer. Med Sci Monit 2016;22:3140–3146. DOI: 10.12659/msm.897486.
  26. Mekki MS, Mougel A, Vinchent A, et al. “Hypoxia leads to decreased autophosphorylation of the MET receptor but promotes its Resistance to tyrosine Kinase Inhibitors.” Oncotarget 2018;43:27039–27058. DOI: 10.18632/oncotarget.25472.
  27. Greijer AE, P van der Groep, Kemming D, et al. “Up-Regulation of Gene Expression by Hypoxia Is Mediated Predominantly by Hypoxia-Inducible Factor 1 (HIF-1).” J Pathol 2005;206(3):291–304. DOI: 10.1002/path.1778.
  28. Cosgrove, D. Angiogenesis imaging-Ultrasound. Br J Radiol 2003;76 Spec No 1:S43–S49. DOI: 10.1259/bjr/86364648.
  29. Kerimog U, Akata D, Hazirolan T, et al. Evaluation of radiotherapy response of cervical carcinoma with gray scale and color Doppler ultrasonography: Resistive index correlation with magnetic resonance findings. Diagn Interv Radiol 2006;12(3):155–160. PMID: 16972223.
  30. Zhuang L, Ly R, Rösl F,et al. p53 Is Regulated in a Biphasic Manner in Hypoxic Human Papillomavirus Type 16 (HPV16)-Positive Cervical Cancer Cells. Int J Mol Sci 2020;21(24):9533. DOI: 10.3390/ijms21249533..
  31. Lu ZH, Wright JD, Belt B, et al. “Hypoxia-Inducible Factor-1 Facilitates Cervical Cancer Progression in Human Papillomavirus Type 16 Transgenic Mice.” Am J Pathol 2007;171(2):667–681. DOI: 10.2353/ajpath.2007.061138.
  32. Saini Y, Chen J, Patial S. The tristetraprolin family of RNA-binding proteins in cancer: Progress and future prospects. Cancers (Basel) 2020;12(6):1539. DOI: 10.3390/cancers12061539..
  33. Yan B, Ma QF, Tan WF, et al. “Expression of protein HIF-1α is a predictive marker of the efficacy of neoadjuvant chemotherapy for locally advanced cervical cancer.” Oncol Lett 2020;20(1):841–849. DOI: 10.3892/ol.2020.11596..
  34. Dellas K, Bache M, Pigorsch SU, et al. Prognostic impact of HIF-1alpha expression in patients with definitive radiotherapy for cervical cancer. Strahlenther Onkol 2008;184(3):169–174. DOI: 10.1007/s00066-008-1764-z.
  35. Winata I G S, Budiana ING, Jawi IM, et al. “Neoadjuvant chemotherapy in stadium IB3, IIA2 and IIB cervical cancer a narrative review.” Biomed Pharmacol J 2022;15(2):901–910. DOI: https://dx.doi.org/10.13005/bpj/2425.
  36. Winata IGS, Hidayat YM, Winarno GN, et al. Pulsatility index and hypoxia inducible factor-1α expression predict the clinical response after external radiation in patients with stage IIB to IVA cervical cancer. Asian Pac J Cancer Prev 2019;20(7):2073–2078. DOI: 10.31557/APJCP.2019.20.7.2073.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.