Journal of South Asian Federation of Obstetrics and Gynaecology

Register      Login

VOLUME 15 , ISSUE 4 ( July-August, 2023 ) > List of Articles

Original Article

Pregnancy Outcomes of Intracytoplasmic Sperm Injection in the Reproductive Medicine Unit of a Tertiary Care Center

Devika Vijayan, Prema Nalligounder, Reji Mohan, Sheila Balakrishnan

Keywords : Cesarean delivery, Intracytoplasmic sperm injection, Miscarriage, Multiple pregnancy

Citation Information : Vijayan D, Nalligounder P, Mohan R, Balakrishnan S. Pregnancy Outcomes of Intracytoplasmic Sperm Injection in the Reproductive Medicine Unit of a Tertiary Care Center. J South Asian Feder Obs Gynae 2023; 15 (4):433-435.

DOI: 10.5005/jp-journals-10006-2294

License: CC BY-NC 4.0

Published Online: 16-09-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Aims and objectives: To study and quantify the fetomaternal outcomes of intracytoplasmic sperm injection (ICSI) conceptions. Methodology: Descriptive study of the fetomaternal outcomes was done in 60 ICSI conceived patients and percentage of each outcome was calculated and the major outcome was identified. Results: Out of 60 ICSI conceived subjects (n = 60), 8.3% of patients had biochemical pregnancies, 1.7% had anembryonic pregnancies and 18.3% of patients had missed abortions. About 3.3% had cervical insufficiency and preterm premature rupture of membranes (PPROM). About 8.3% had gestational diabetes mellitus. And 3.3% had placenta previa, 20% of women experienced preterm birth, 21.7% experienced multiple pregnancies,1.7% experienced intrauterine death. About 56.7% had cesarean delivery; 21.7% had NICU admissions due to prematurity followed by sepsis, low birth weight, and jaundice. About 1.7% of babies had congenital anomalies, 67% of mothers experienced live births and 3.33% had neonatal deaths; 80% of the babies weighed between 2.5 and 4 kg. We did not have cases of ectopic pregnancy which can be due to proper technique of embryo transfer. No cases of placental abruption, intrauterine growth restriction (IUGR), stillbirth, and eclampsia due to the use of antenatal aspirin. The major outcomes from this study were cesarean delivery (56.7%), followed by miscarriages (28.3%) and multiple pregnancy (17%). Conclusion: The major outcomes of ICSI pregnancies were cesarean delivery (56.7%), followed by miscarriages (28.3%) and multiple pregnancy (17%). Clinical significance: This review summarizes the data available on the fetomaternal outcomes after ICSI and also the follow-up of assisted reproductive techniques pregnancies.

PDF Share
  1. Sara Hodin. The Burden of Infertility: Global Prevalence and Women's Voices from Around the World. Maternal Health Task Force. 2017.
  2. WHO. Global prevalence of infertility, infecundity and childlessness WHO. 2019 Oct 20.
  3. Infertility National Health Portal of India [Internet]. Available from:
  4. Broughton DE, Moley KH. Obesity and female infertility: potential mediators of obesity's impact. Fertil Steril 2017;107(4):840–847. DOI: 10.1016/j.fertnstert.2017.01.017.
  5. Krausz C, Riera-Escamilla A. Genetics of male infertility. Nat Rev Urol 2018;15(6):369–384. DOI: 10.1038/s41585-018-0003-3.
  6. Sharma RS, Saxena R, Singh R. Infertility and assisted reproduction: a historical and modern scientific perspective. Indian J Med Res. 20188(Suppl 1):S10–S14. DOI: 10.4103/ijmr.IJMR_636_18.
  7. Chai J, Lee VC-Y, Yeung TW-Y, et al. Live birth and cumulative live birth rates in expected poor ovarian responders defined by the Bologna criteria following IVF/ICSI treatment. PLoS One 2015;10(3):e0119149. DOI: 10.1371/journal.pone.0119149.
  8. National Summary Report Available from:
  9. Yuzpe AA, Brown SE, Casper RF, et al. Rates and outcome of pregnancies achieved in the first 4 years of an in-vitro fertilization program. CMAJ Can Med Assoc J 1989;140(2):167–172. PMID: 2910399.
  10. Engmann L, Maconochie N, Tan SL, et al. Trends in the incidence of births and multiple births and the factors that determine the probability of multiple birth after IVF treatment. Hum Reprod 2001;16(12):2598–2605. DOI: 10.1093/humrep/16.12.2598.
  11. Gupta P, Nayan N, Sharma M. Perinatal outcomes among children born by assisted reproductive techniques—a hospital-based case control study. Med J Armed Forces India 2012;68(2):132–135. DOI: 10.1016/S0377-1237(12)60019-7.
  12. Omani-Samani R, Alizadeh A, Almasi-Hashiani A, et al. Risk of preeclampsia following assisted reproductive technology: systematic review and meta-analysis of 72 cohort studies. J Matern Fetal Neonatal Med 2020;33(16):1–15. DOI: 10.1080/14767058.2018.1560406.
  13. Zhu L, Zhang Y, Liu Y, et al. Maternal and live birth outcomes of pregnancies following assisted reproductive technology: a retrospective cohort study. Sci Rep 2016;6:35141. DOI: 10.1038/srep35141.
  14. Wang YA, Nikravan R, Smith HC, et al. Higher prevalence of gestational diabetes mellitus following assisted reproduction technology treatment. Hum Reprod 2013;28(9):2554–2561. DOI: 10.1093/humrep/det270.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.