Journal of South Asian Federation of Obstetrics and Gynaecology

Register      Login

VOLUME 15 , ISSUE 3 ( May-June, 2023 ) > List of Articles


Ovarian Hyperstimulation Syndrome in Voluntary Ovum Donors: A Case Series

Subhani Mahapatra, Arun Harishchandra Nayak

Keywords : Assisted reproductive technology cycles, Ovarian hyperstimulation syndrome, Ovum donor

Citation Information : Mahapatra S, Nayak AH. Ovarian Hyperstimulation Syndrome in Voluntary Ovum Donors: A Case Series. J South Asian Feder Obs Gynae 2023; 15 (3):368-371.

DOI: 10.5005/jp-journals-10006-2236

License: CC BY-NC 4.0

Published Online: 31-07-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Aim: The aim of this study was to report a case series of ovarian hyperstimulation syndrome in voluntary oocyte donors and discuss their management and clinical course. Background: Ovarian hyperstimulation syndrome is a rare, iatrogenic complication occurring in artificial reproductive technology cycles. Recently, with the boost in the use of oocyte donors in ART, it has been noted that voluntary oocyte donors who undergo controlled ovarian hyperstimulation to induce superovulation in them are increasingly suffering from this syndrome. This syndrome varies from mild-to-severe and may become potentially lethal, the pathophysiologic hallmark of which is the accumulation of massive extravascular exudate combined with profound intravascular volume depletion. Case description: Seven voluntary oocyte donors who have undergone multiple cycles of superovulation and oocyte retrieval presented with moderate-to-severe ovarian hyperstimulation syndrome (OHSS) and required admission. Clinical examination and ultrasonography confirmed the diagnosis of ovarian hyperstimulation syndrome. Most of these patients were optimally managed by conservative methods while two developed complications and required emergency laparotomy. Clinical significance: With proper precautions and early detection, the deleterious effects of this condition can be prevented, and progression to a life-threatening ailment can be avoided. Donors must be thoroughly investigated and their donations must be well-spaced to avoid these negative impacts on their health. Understanding this condition will allow better management of donors at ART centers and prompt recognition of such complications by the clinician.

  1. Tober D, Garibaldi C, Blair A, et al. Alignment between expectations and experiences of egg donors: What does it mean to be informed? Reprod Biomed Soc Online 2021;12:1–13. DOI:
  2. Viatios NF, Grecorio O. Prevention and management of ovarian hyperstimulation syndrome. Ann NY Acad Sci 2006;1092: 247–264. DOI:
  3. Sauer MV, Paulson RJ, Lobo RA. Rare occurrence of ovarian hyperstimulation syndrome in oocyte donors. Int J Gynaecol Obstet 1996;52:259–262. DOI:
  4. Wadhwa ED, Bhosale AA, Khade SA, et al. A fatal case of ovarian hyperstimulation syndrome. J South Asian Feder Obst Gynae 2022;14(5):611–613. DOI: 10006-2108.
  5. Golan A, Ronel R, Herman A, et al. Ovarian hyperstimulation syndrome: An update review. Obstet Gynecol Surv 1989;44:430–440. DOI:
  6. Gul T, Ugurel V. A case of ovarian hyperstimulation syndrome in a patient with polycystic ovarian syndrome. Turkish Med Stud j 2015;23–26.
  7. Gichuhi JW, Wanyoike SW, Ndegwa S. Ovarian hyperstimulation syndrome: A case report. East African Med J 2015;91:39–42.
  8. Kanayama S, Kaniwa H, Tomimoto M, et al. Laparoscopic detorsion of the ovary in ovarian hyperstimulation syndrome during the sixth week of gestation: A case report and review. Int J Surg Case Rep 2019;59:50–53. DOI:
  9. Garg R, Singh S, Jain M. Cabergoline for ovarian hyperstimulation: a review of clinical evidence. J South Asian Feder Obst Gynae 2015;7(1):30–32. DOI: 10.5005/jp-journals-10006-1317.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.