Rare and Multiple Alloimmunization in Antenatal Women: A Case Report

Swati Garg; Vidisha Payal; Urvashi Sharma; Ram Mohan Jaiswal

doi:10.5005/jp-journals-10006-2254

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Rare and Multiple Alloimmunization in Antenatal Women: A Case Report

Swati Garg, Vidisha Payal, Urvashi Sharma, Ram Mohan Jaiswal

Keywords : Alloimmunization, Anti-U antibody, Antibody prophylaxis, Antibody screening, Foetal anemia

Citation Information : Garg S, Payal V, Sharma U, Jaiswal RM. Rare and Multiple Alloimmunization in Antenatal Women: A Case Report. J South Asian Feder Obs Gynae 2023; 15 (3):362-364.

DOI: 10.5005/jp-journals-10006-2254

License: CC BY-NC 4.0

Published Online: 31-07-2023

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Abstract

Maternal alloimmunization is uncommon and highly variable, and general obstetricians are not familiar with, non-ABO, non-D alloimmunization. Therefore, when a woman with anti-D alloimmunization, who has received antibody prophylaxis, still develops fetal anemia in a subsequent pregnancy, it is commonly labeled as inadequate prophylaxis or a coincidental non-immune cause of fetal anemia. We report a similar case of unusual and multiple alloimmunization, where anti-D, anti-C, and anti-U antibodies were present resulting in hemolytic disease of the fetus and newborn (HDFN). The case emphasizes the need for routine and periodic antibody screening in all pregnant women, irrespective of their ABO and Rh status, which will allow monitoring from early pregnancy and timely intervention to avoid poor fetal and neonatal outcomes.

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Hendrickson JE, Delaney M. Hemolytic disease of the fetus and newborn: modern practice and future investigations. Transfus Med Rev 2016;30(4):159–164. DOI: 10.1016/j.tmrv.2016.05.008.
Michelle L. Erickson. Alloimmunization in Pregnancy. Immunologic Concepts in Transfusion Medicine, 2020;149–165. DOI: https://doi.org/10.1016/B978-0-323-67509-3.00009-3.
Agarwal K, Rana A, Ravi AK. Treatment and prevention of Rh isoimmunization. J Fetal Med 2014;1:81–88. DOI: https://doi.org/10.1007/s40556-014-0013-z.
Karim F, Moiz B, Kamran N. Risk of maternal alloimmunization in Southern Pakistan – A study in a cohort of 1000 pregnant women. Transfus Apher Sci 2015;52(1):99–102. DOI: 10.1016/j.transci.2014.12.002.
Suresh B, Sreedhar Babu KV, Arun R, et al. Prevalence of “unexpected antibodies” in the antenatal women attending the Government Maternity Hospital, Tirupati. Journal of Clinical and Scientific Research 2015;4(1):22–30. DOI: 10.15380/2277-5706.JCSR.14.041.

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