Introduction: Antioxidant can be defined as any substance that significantly delays and prevents the oxidation of an oxidizable substrate (oxidant). So that the causal relationship of menopause and the imbalance of oxidant–antioxidant becomes a reciprocal relationship and influences each other, decreases in antioxidant levels have been researched can cause oxidative stress, which triggers apoptosis in ovarian reserves. Objective: The purpose of this study is to compare the serum total antioxidant capacity (TAC) levels between early-menopausal and normal-menopausal women. Methods: This is an observational analytic study with a case–control design with 20 women with early menopause and normal menopause were included according to the inclusion and exclusion criteria by consecutive sampling, then the characteristic data were collected and grouped according to the study group. A blood test was done to assess serum TAC in the participants. Data were collected and processed, and statistical analysis was carried out. Results: It was found that there were differences in age at menopause in the group of participants who experienced early menopause and normal menopause. There were differences in TAC levels based on body mass index and TAC levels in early menopause and normal menopause. Conclusion: There are differences in serum TAC levels between early menopausal and normal menopausal women.