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VOLUME 15 , ISSUE 1 ( January-February, 2023 ) > List of Articles

REVIEW ARTICLE

The Role of Epigenetics in Endometriosis

Ni Luh Wita Astari Widhusadi, Anak Agung Ngurah Anantasika

Keywords : Endometriosis, Epigenetics, Gene, MicroRNA

Citation Information : Widhusadi NL, Anantasika AA. The Role of Epigenetics in Endometriosis. J South Asian Feder Obs Gynae 2023; 15 (1):88-96.

DOI: 10.5005/jp-journals-10006-2183

License: CC BY-NC 4.0

Published Online: 19-04-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Abstract

Epigenetics is a field that studies that study the changing in the regulation of gene activity and expression that are independent of the DNA sequence of genes and can be inherited or inherited. This refers to a change in phenotypic status that is not based on a change in genotype. Epigenetics is known to have a part in the pathogenesis of endometriosis. Epigenetics can cause endometriosis is known through mechanisms such as DNA methylation, histone modification, and microRNA (miRNA). These various mechanisms are also related to environmental, immune, and hormonal factors that trigger endometriosis. Endometriosis is a gynecological problem involving the stroma of the endometrium and glands which normally line the uterine cavity but is found outside the uterine cavity (endometrial-like tissues). Until now, the etiopathogenesis of endometriosis is still under debate. Etiopathogenesis of endometriosis is said to be related to the genetic system and epigenetic abnormalities. Reversibility is the key to epigenetic change therefore it is used as a potential epigenetic therapy option. Enzymes that control epigenetic change are the goal of studies into pharmacological interventions in endometriosis. Therefore, the role of epigenetics requires further attention in the diagnosing, management, and prognosis of endometriosis condition so that the patient's quality of life will be better.

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