Citation Information :
Subhedhar SS, Patra S, Shrimali T. Diagnostic Accuracy of TVS-based Soft Markers in the Evaluation of Women with Chronic Pelvic Pain. J South Asian Feder Obs Gynae 2023; 15 (1):81-84.
Objective: To determine the diagnostic accuracy of transvaginal ultrasonography (TVS)-based soft markers and its correlation with diagnostic laparoscopy in the detection of pelvic pathology and the evaluation of women with chronic pelvic pain (CPP).
Materials and methods: A prospective observational study was conducted in the Department of Obstetrics and Gynaecology, Lady Hardinge Medical College, New Delhi, in which a total of 100 women between the ages of 18 and 50 with complaints of CPP lasting for more than 6 months, fulfilling the inclusion criteria were enrolled. Women were first subjected to clinical examination followed by TVS soft marker analysis, i.e., site-specific pelvic tenderness, ovarian mobility, and presence of loculated peritoneal fluid in the pelvis. Those who had either presence of TVS soft markers or clinical findings, or both, underwent diagnostic laparoscopy to see for pelvic pathology. Transvaginal ultrasonography soft marker findings were correlated with diagnostic laparoscopy and subjected to statistical analysis.
Results: The mean age of the total study population was 30.9 + 4.02 years and mean duration of abdominal pain was 3.66 + 3.06 years. Transvaginal ultrasonography soft markers were present in 85 women in whom Laparoscopy confirmed pelvic pathology in 75 women, with 51 had minimal adhesions, 14 had subtle endometriotic lesions, and 10 had pelvic congestion. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of TVS soft markers were 100%, 68%, 90%, and 100% with p < 0.001. The diagnostic accuracy of TVS soft markers was 92% with a likelihood ratio of 3.13 and a good correlation was established between TVS soft markers and laparoscopic findings (κ = 0.69) (p < 0.001).
Conclusion: In conclusion, TVS-based soft markers should be regarded as the first line imaging modality in the evaluation of patients with suspected endometriosis and pelvic adhesions as this could facilitate more effective triaging of women, resulting in shorter, safer, more rational, and cost-effective management and in turn reduce the need for invasive procedures like laparoscopy for evaluation of CPP.
Reiter RC. A profile of women with chronic pelvic pain. Clin Obstet Gynecol 1990;33:130–136. PMID: 2178830.
Roseff SJ, Murphy AA. Laparoscopy in the diagnosis and therapy of chronic pelvic pain. Clin Obstet Gynecol 1990;33:137–144. DOI: 10.1097/00003081-199003000-00019.
Chronic pelvic pain. ACOG Practice Bulletin No. 218. American College of Obstetricians and Gynecologists. Obstet Gynecol 2020;135: e98–e109. DOI: 10.1097/AOG.0000000000003716.
Zondervan KT, Yudkin PL, Vessey MP, et al. Prevalence and incidence of chronic pelvic pain in primary care: Evidence from a national general practice database. Br J Obstet Gynaecol 1999;106:1149–1155. DOI: 10.1111/j.1471-0528.1999.tb08140.x.
Lundberg WI, Wall JE, Mathers JE. Laparoscopy in evaluation of pelvic pain. Obstet Gynecol 1973;42:872–876. PMID: 4271278.
Hyslop RS. Some thoughts on pelvic pain. Aust N Z J Obstet Gynaecol 1972;12:402. DOI: 10.1111/j.1479-828x.1972.tb00727.x.
Dubrovina SO, Berlim YD, Bezhenar VF, et al. Pharmacological management of endometriosis-related pain: The expert opinion. J South Asian Feder Obst Gynae 2020;12(6):415–420. https://doi.org/10.5005/jp-journals-10006-1838.
Goel JK, Goel S. Chronic pelvic pain: an overview. J South Asian Feder Obst Gynae 2013;5(3):147–153. DOI: 10.5005/jp-journals-10006-1249.
Okaro E, Condous G, Khalid A, et al. The use of ultrasound based soft markers for the prediction of pelvic pathology in women with chronic pelvic pain – can we reduce the need for laparoscopy? Br J Obstet Gynecol 2006;113:251−256. DOI: 10.1111/j.1471-0528.2006.00849.x.
Kamel HS, Abu-Elhassan AM, Abdel-Aleema MA, et al. Sonographic and laparoscopic findings in women presenting with chronic pelvic pain. J Cur Med Res Pract 2017;2(3):186−191. DOI: 10.4103/JCMRP.JCMRP_70_17.
Said TH, Amal Z Azzam. Prediction of endometriosis by transvaginal ultrasound in reproductive-age women with normal ovarian size. Middle East Fertil Soc J 2014;19(3):197−207. http://dx.doi.org/10.1016/j.mefs.2013.11.003.
Hebbar S, Chawla C. Role of laparoscopy in evaluation of chronic pelvic pain. J Min Access Surg 2005;1(3):116−120. DOI: 10.4103/0972-9941.18995.
Chhetri S, Khanna S, Poonam A, et al. Laparoscopic evaluation of chronic pelvic pain in women. J Nepal Health Res Counc 2009;7(1): 45–48. DOI:10.3126/jnhrc.v7i1.2279.
Zubor P, Szunyogh N, Galo S, et al. Laparoscopy in chronic pelvic pain–a prospective clinical study. Ceska Gynekol 2005;70:225−231. PMID: 16047928.
Shugufa RY, Sultana S, Rashid S, et al. A comparative study of transvaginal sonography versus laparoscopy evaluation in chronic pelvic pain: Original study. Int J Clin Exp Med Sci 2015;1(1):4−6. DOI: 10.11648/j.ijcems.20150101.12.
Marasinghe JP, Senanayake H, Saravanabhava N, et al. Mobility of ovaries. J Obstet Gynaecol Res 2014;40:785−790. DOI: 10.1111/jog. 12234.
Gerges B, Lu C, Reid S, et al. Sonographic evaluation of immobility of normal and endometriotic ovary in detection of deep endometriosis. Ultrasound Obstet Gynecol 2017;49:793−798. DOI: 10.1002/uog.15990.