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VOLUME 14 , ISSUE 6 ( November-December, 2022 ) > List of Articles
Reshmi Shanmugham, Rupal Samal, Divya Alamelu
Keywords : Dinoprostone, Prostaglandin, Vaginal pH, Vaginal washing
Citation Information : Shanmugham R, Samal R, Alamelu D. Dinoprostone Intravaginal Slow-release Insert for Labor Induction with and without Saline Vaginal Wash: A Randomized Controlled Trial. J South Asian Feder Obs Gynae 2022; 14 (6):700-703.
License: CC BY-NC 4.0
Published Online: 31-01-2023
Copyright Statement: Copyright © 2022; The Author(s).
Aim: To study the outcome of intravaginal dinoprostone insert for induction of labor with and without a saline vaginal wash. Materials and methods: A randomized controlled trial was conducted from October 2019 to June 2021 in the Department of Obstetrics and Gynaecology of a tertiary care center located in Puducherry, India. The total study population was 164. Participants were allocated into group I (n = 82) and group II (n = 82) based on computer-generated random numbers. A 20 mL of 0.9% NaCl wash was given intravaginally prior to insertion of dinoprostone for group I and no wash was given for group II. Duration of dinoprostone kept intravaginally, time from insertion to active stage, and full cervical dilatation was noted. The software used was statistical package for social sciences (SPSS) software, version 17. Results: Group I patients were found to attain the active stage of labor in 10 hours compared to group II patients who attained the active stage of labor in 14 hours. The difference between the mean duration of dinoprostone kept intravaginally, insertion to the active stage and full cervical dilatation were statistically significant. Conclusion: Thus, the labor duration for patients who underwent vaginal wash was less when compared to those who did not undergo vaginal washing. Vaginal pH has been shown to alter with vaginal washing. Vaginal washing before intravaginal dinoprostone insertion may increase the vaginal pH, and change the prostaglandin E2 (PGE2) vaginal insert bioavailability leading to shorter labor duration. Clinical significance: For pregnant women with planned labor induction, vaginal douching can be easily performed before intravaginal dinoprostone insertion and can provide safe and rapid labor.