Changing Prevalence of Emergency Obstetric Hysterectomy, Its Indications and Maternal Outcomes Over a 4-year Period at a Tertiary Care Center in Pakistan
Citation Information :
Ala SH, Husain S, Hussain S. Changing Prevalence of Emergency Obstetric Hysterectomy, Its Indications and Maternal Outcomes Over a 4-year Period at a Tertiary Care Center in Pakistan. J South Asian Feder Obs Gynae 2022; 14 (6):690-693.
Aim: The aim of this study is to assess the prevalence, indications, and maternal outcome of emergency obstetrics hysterectomy and to determine the change in trend in indications of emergency obstetrics hysterectomy in a tertiary care center in Pakistan.
Materials and methods: This retrospective, observational analytical study was conducted in the Department of Obstetrics and Gynecology – Unit-III of Dr Ruth KM Pfau Civil Hospital, Karachi, Pakistan from 2016 to 2019. All patients who had undergone emergency obstetrical hysterectomy from January 2016 to December 2019 were enrolled in the study. Data were collected from files and registers. The rate for emergency obstetric hysterectomy (EOH) was calculated. The indications for hysterectomy were also noted. Maternal outcomes including injury to organs, transfusions of blood and its products, intensive care unit (ICU) admissions, and maternal death were secondary outcome measures.
Results: Over a 4-year period between January 2016 to December 2019, 15,040 women were delivered, and out of these, 202 underwent EOH. The prevalence of EOH was 13.42 per 1,000 deliveries. The rate was 0.37% in 2016, 0.58% in 2017, 1.76% in 2018, and 2.48% in 2019. Overall, the most common indication for hysterectomy was morbidly adherent placenta (MAP) 64 (31.7%) followed by postpartum hemorrhage 60 (29.7%). There was a gradual change in indications for EOH; in 2016 only one EOH was due to MAP, whereas in 2019, 34 (33%) EOHs were due to MAP. Out of these 202 women, 29 (14.4%) succumbed to death.
Conclusion: There was a sharp increase in the rate of EOH from 2016 (0.37%) to 2019 (2.48%). Morbidly adherent placenta has become the leading indication for EOH. Policymakers need to take necessary action to reduce the cesarean section rate.
Lone F, Sultan AH, Thakar R, et al. Risk factors and management patterns for emergency obstetric hysterectomy over 2 decades. Int. J Gynecol Obstet 20101;109(1):12–15. DOI: 10.1016/j.ijgo.2009.10.012.
Kayabasoglu F, Guzin K, Aydogdu S, et al. Emergency peripartum hysterectomy in a tertiary Istanbul hospital. Arch Gynecol Obstet 2008;278(3):251–256. DOI: 10.1007/s00404-007-0551-x.
Chawla J, Arora CD, Paul M, et al. Emergency obstetric hysterectomy: A retrospective study from a teaching hospital in North India over eight years. Oman Med J 2015;30(3):181. DOI: 10.5001/omj.2015.39.
Huque S, Roberts I, Fawole B, et al. Risk factors for peripartum hysterectomy among women with postpartum haemorrhage: Analysis of data from the WOMAN trial. BMC pregnancy and childbirth. 2018;18(1):186. DOI: 10.1186/s12884-018-1829-7.
Callaghan WM, Kuklina EV, Berg CJ. Trends in postpartum hemorrhage: United States, 1994–2006. Am J Obstet Gynecol 2010;202(4):353.e1–353.e6. DOI: 10.1016/j.ajog.2010.01.011.
Say L, Chou D, Gemmill A, et al. Global causes of maternal death: A WHO systematic analysis. Lancet Glob Health 2014;2(6):e323–e333. DOI: 10.1016/S2214-109X(14)70227-X.
Mehrabadi A, Hutcheon JA, Lee L, et al. Epidemiological investigation of a temporal increase in atonic postpartum haemorrhage: A population-based retrospective cohort study. BJOG 2013;120(7):853–862. DOI: 10.1111/1471-0528.12149.
Kramer MS, Berg C, Abenhaim H, et al. Incidence, risk factors, and temporal trends in severe postpartum hemorrhage. Am J Obstet Gynecol 2013;209(5):449.e1–449.e7. DOI: 10.1016/j.ajog.2013.07.007.
Rahman J, Al-Ali M, Qutub HO, et al. Emergency obstetric hysterectomy in a university hospital: A 25-year review. J Obstet Gynaecol 2008;28(1):69–72. DOI: 10.1080/01443610701816885.
Zeteroglu S, Ustun Y, Engin–Ustun Y, et al. Peripartum hysterectomy in a teaching hospital in the eastern region of Turkey. Eur J Obstet Gynecol Reprod Biol 2005;120(1):57–62. DOI: 10.1016/j.ejogrb.2004.08.011.
Sakse A, Weber T, Nickelsen C, et al. Peripartum hysterectomy in Denmark 1995–2004. Acta Obstet Gynecol Scand 2007;86(12):1472–1475. DOI: 10.1080/00016340701692651.
Campbell SM, Corcoran P, Manning E, et al. Peripartum hysterectomy incidence, risk factors and clinical characteristics in Ireland. Eur J Obstet Gynecol Reprod Biol 2016;207:56–61. DOI: 10.1016/j.ejogrb.2016.10.008.
Knight M, Kurinczuk JJ, Spark P, et al. Cesarean delivery and peripartum hysterectomy. Obstet Gynecol 2008;111(1):97–105. DOI: 10.1097/01.AOG.0000296658.83240.6d.
Sahin S, Guzin K, Eroğlu M, et al. Emergency peripartum hysterectomy: Our 12-year experience. Arch Gynecol Obstet 2014;289(5):953–958. DOI: 10.1007/s00404-013-3079-2.
Wen SW, Huang L, Liston R, et al. Severe maternal morbidity in Canada, 1991–2001. CMAJ. 2005;173(7):759–764. DOI: 10.1503/cmaj.045156.
Whiteman MK, Kuklina E, Hillis SD, et al. Incidence and determinants of peripartum hysterectomy. Obstet Gynecol 2006;108(6):1486–1492. DOI: 10.1097/01.AOG.0000245445.36116.c6.
Awan N, Bennett MJ, Walters WA. Emergency peripartum hysterectomy: A 10-year review at the Royal Hospital for Women, Sydney. Aust N Z J Obstet Gynaecol 2011;51(3):210–215. DOI: 10.1111/j.1479-828X.2010.01278.x.
Khan B, Khan B, Sultana R, et al. A ten year review of emergency peripartum hysterectomy in a tertiary care hospital. J Ayub Med Coll Abbottabad 2012;24(1):14–17. PMID: 23855085.
Cara Z, Thompson EL, O’Rourke K, et al. Cesarean section and the risk of emergency peripartum hysterectomy in high-income countries: A systematic review. Arch Gynecol Obstet 2015;292(6):1201–1215. DOI: 10.1007/s00404-015-3790-2.
Demirci O, Tuğrul AS, Yılmaz E, et al. Emergency peripartum hysterectomy in a tertiary obstetric center: Nine years evaluation. J Obstet Gynaecol Res 2011;37(8):1054–1060. DOI: 10.1111/j.1447-0756.2010.01484.x.
Zhang Y, Yan J, Han Q, et al. Emergency obstetric hysterectomy for life-threatening postpartum hemorrhage: A 12-year review. Medicine 2017;96(45):e8443. DOI: 10.1097/MD.0000000000008443.
Bodelon C, Bernabe-Ortiz A, Schiff MA, et al. Factors associated with peripartum hysterectomy. Obstet Gynecol 2009;114(1):115. DOI: 10.1097/AOG.0b013e3181a81cdd.
Kwee A, Bots ML, Visser GH, et al. Emergency peripartum hysterectomy: A prospective study in The Netherlands. Eur J Obstet Gynecol Reprod Biol 2006;124(2):187–192. DOI: 10.1016/j.ejogrb.2005.06.012.
Zorlu CG, Turan C, Işik A, et al. Emergency hysterectomy in modern obstetric practice changing clinical perspective in time. Acta Obstet Gynecol Scand 1998;77(2):186–190. PMID: 9512325.
Shah N, Khan NH. Emergency Obstetric Hysterectomy: A review of 69 cases. Rawal Med J 2009;34:75–78.
Korejo R, Nasir A, Yasmin H, et al. Emergency obstetric hysterectomy. J Pak Med Assoc 2012;62(12):1322–1325. PMID: 23866483.
Kazi S. Emergency peripartum hysterectomy: A great obstetric challenge. Pakistan J Med Sci 2018;34(6):1567–1570. DOI: 10.12669/pjms.346.13686.
Betrán AP, Torloni MR, Zhang JJ, et al. WHO statement on caesarean section rates. BJOG 2016;123(5):667. DOI: 10.1111/1471-0528.13526.
Betran AP, Ye J, Moller A, et al. Trends and projections of caesarean section rates: Global and regional estimates. BMJ Glob Health 2021;6:e005671. DOI: 10.1136/bmjgh-2021-005671.