Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 14 , ISSUE 4 ( July-August, 2022 ) > List of Articles

Original Article

Perinatal Outcomes of Patients with Hepatitis B Viral Infection in Pregnancy

Ashima K Thuruthayil

Keywords : Hepatitis B, Hepatitis B surface antigen, Lower-segment cesarean section, Pregnancy, Prematurity

Citation Information : Thuruthayil AK. Perinatal Outcomes of Patients with Hepatitis B Viral Infection in Pregnancy. J South Asian Feder Obs Gynae 2022; 14 (4):349-355.

DOI: 10.5005/jp-journals-10006-2015

License: CC BY-NC 4.0

Published Online: 22-08-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Purpose: Hepatitis B virus (HBV) virus has been established to infect about 350 million individuals on a worldwide scale. Nearly half of the infection is acquired either perinatally or in early childhood. The infection represents a significant cause of cirrhosis and hepatocellular carcinoma–related morbidity and mortality. Materials and methods: This is a retrospective record study conducted at a tertiary care hospital (St John's Medical College Hospital, Bengaluru) by review of records over the past 5 years (January 2015–June 2021). Results: We identified 85 pregnant women diagnosed as HBsAg-positive during our study period; of which 67 (78.8) patients were <30 years of age while the remaining 18 (21.2) were >30 years of age. The mean gestational age at the time of admission was 37.6 ± 2.5 weeks of gestation. Women who were >30 years of age who are married for >5 years 10 (55.6) and those who are <30 years of age and married for 1–5 years 33 (49.3) were HBsAg-positive, p = 0.014b. It was noticed that gamma-glutamyl transferase was two times elevated in primigravida when compared to multigravida, which was statistically significant (p = 0.037). Meconium-stained liquor 3 (3.5) was the most common intraoperative finding seen in pregnant women who were HBsAg-positive. Conclusion: The development of chronic hepatitis B infection is inversely proportional to the age at which infection occurs. Close monitoring of liver function tests, particularly gamma-glutamyl transferase and antepartum fetal surveillance is important to increase the chance of good outcomes in these pregnancies. Key message: The better association of gamma-glutamyl transferase to obstetric score in HBsAg-positive pregnant women.


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