Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 14 , ISSUE 4 ( July-August, 2022 ) > List of Articles


Case-control Association Study of TLR4 (rs 1927914) Polymorphism with the Risk of Low Birth Weight and Fetal Growth Restriction in North Indian Women

Anupama, Uma Pandey, Kiran Singh, Deepak Singh Patel

Keywords : Fetal growth restriction, Low birth weight, Single-nucleotide polymorphism, Toll-like receptors

Citation Information : Anupama, Pandey U, Singh K, Patel DS. Case-control Association Study of TLR4 (rs 1927914) Polymorphism with the Risk of Low Birth Weight and Fetal Growth Restriction in North Indian Women. J South Asian Feder Obs Gynae 2022; 14 (4):410-414.

DOI: 10.5005/jp-journals-10006-2074

License: CC BY-NC 4.0

Published Online: 22-08-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Background: Compared to newborns of normal birth weight at term gestation, the mortality and morbidity rates for low birth weight (LBW) and fetal growth restriction (FGR) babies are absurdly high. This is because these babies are more vulnerable to infections. Aims and objectives: To study the association of toll-like receptor (TLR) 4 gene T>C (rs 1927914) polymorphism with the risk of LBW and FGR at term gestation in north Indian women. Materials and methods: One hundred and eighty-two pregnant women (50 LBW and 32 FGR cases and 100 controls), 18–45 years of age, who attended the antenatal clinic or labor room were studied. We studied different maternal factors like maternal height, body mass index, number of antenatal visits, pre-pregnancy weight, and weight gain during pregnancy. In newborns, parameters like birth weight, gender, Apgar score after 1 and 5 minutes, NICU admission, and different anthropometric data were assessed. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was studied to analyze the single-nucleotide polymorphism of TLR4 (rs1927914) T>C. Results: There was no significant association between TLR4 (rs 1927914) T>C polymorphism and risk of LBW and FGR. Genotype, TC, and CC of TLR4 T>C polymorphism showed a slight increase in the risk of LBW (p = 0.38). Conclusions: The present study suggests that several inter-related factors increase the risk of LBW and FGR. The complex interplay and co-existence of many maternal and fetal factors are the leading cause of the increased risk of LBW and intrauterine growth restriction. Early prediction, identification of these risk factors, and proper management may prevent infant morbidities.

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