Journal of South Asian Federation of Obstetrics and Gynaecology

Register      Login

VOLUME 14 , ISSUE 3 ( May-June, 2022 ) > List of Articles


A Prospective Cohort Study of Etiology and Neonatal Outcome of Preterm Labor in a Tertiary-care Hospital Attached to a Medical College

Srijana Mathai, Rachel Mathew, Suja M Mani, NS Sreedevi

Keywords : Preterm birth, Preterm labor, Preterm mothers

Citation Information : Mathai S, Mathew R, Mani SM, Sreedevi N. A Prospective Cohort Study of Etiology and Neonatal Outcome of Preterm Labor in a Tertiary-care Hospital Attached to a Medical College. J South Asian Feder Obs Gynae 2022; 14 (3):253-256.

DOI: 10.5005/jp-journals-10006-2022

License: CC BY-NC 4.0

Published Online: 30-07-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Background: Preterm labor is a major determinant of neonatal mortality and morbidity worldwide, especially in developing countries. Aims: The study aimed at finding out the incidence and the etiological risk factors responsible for preterm labor that could be targeted to reduce its risk. Materials and methods: In this prospective cohort study of 1 year, a total of 440 antenatal patients diagnosed with preterm labor were included and were followed up. In addition to the known risk factors for preterm labor, investigation data, gestational ages, neonatal outcome, and response to tocolysis if given were noted. The collected data were analyzed using descriptive statistics. Results: The incidence of preterm birth for the current study was 6.7%. The majority of patients were multigravida (59%) and mainly were of the age lesser than 30 years (89.3%). A total of 477 babies including 37 twins were delivered by 440 preterm deliveries of which 377 (79.03%) were live births. About 40.90% of babies had a birth weight in the range of 1.6–2 kg. Neonatal morbidity in preterm babies was 49.33% and was high with patients who had not received steroid coverage (90%) and when the gestational age was less than 34 weeks (72.57%). Similarly, neonatal mortality was found to be 26.52% in preterm babies and was higher in patients who did not receive steroid coverage (63.4%) and also when gestational age was less than 34 weeks (44.18%). Conclusions: Early recognition, appropriate management, and early administration of steroid in high-risk pregnancies along with advice on modifiable etiologies and preconception counseling can bring down preterm birth and thereby reduce neonatal morbidity and mortality.

PDF Share
  1. International classification of diseases and related health problems. 10th revision. Geneva: World Health Organization; 1992.
  2. Petrou S, Mehta Z, Hockley C, et al. The impact of preterm birth on hospital inpatient admissions and costs during the first 5 years of life. Pediatrics 2003;112(6):1290–1297. DOI: 10.1542/peds.112.6.1290.
  3. Petrou S. The economic consequences of preterm birth during the first 10 years of life. BJOG Int J Obstet Gynaecol 2005;112:10–15. DOI: 10.1111/j.1471-0528.2005.00577.x.
  4. Beck S, Wojdyla D, Say L, et al. The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull World Health Organ 2010;88(1):31–38. DOI: 10.2471/BLT.08.062554.
  5. Martin JA, Kochanek KD, Strobino DM, et al. Annual summary of vital statistics–2003. Pediatrics 2005;115(3):619–634. DOI: 10.1542/peds.2004-2695.
  6. The Global Action Report for Preterm Birth. New York, NY, USA: MoD, PMNCH, Save the Children, WHO; 2012. Born too soon.
  7. Sudhir PS, Mishra S. A prospective study of etiology and outcome of preterm labour in a Rural Medical College. Obs Rev J Obstet Gynecol 2016;2(4):44–48. DOI: 10.17511/joog.2016.i04.01.
  8. McPheeters ML, Miller WC, Hartmann KE, et al. The epidemiology of threatened preterm labor: a prospective cohort study. Am J Obstet Gynecol 2005;192(4):1325–1329; discussion 1329-30. DOI: 10.1016/j.ajog.2004.12.055.
  9. Uma S, Nisha S, Shikha S. A prospective analysis of etiology and outcome of preterm labour. J Obstet Gynecol India 2007;57(1):48–52.
  10. Jammeh A, Sundby J, Vangen S. Maternal and obstetric risk factors for low birth weight and preterm birth in rural Gambia: a hospital-based study of 1579 deliveries. Open J Obstet Gynecol 2011;1(03):94. DOI: 10.4236/ojog.2011.13017.
  11. Feresu SA, Harlow SD, Woelk GB. Risk factors for prematurity at Harare maternity hospital, Zimbabwe. Int J Epidemiol 2004;33(6):1194–1201. DOI: 10.1093/ije/dyh120.
  12. Sari IM, Adisasmita AC, Prasetyo S, et al. Effect of premature rupture of membranes on preterm labor: a case-control study in Cilegon, Indonesia. Epidemiol Health 2020;42:e2020025. DOI: 10.4178/epih.e2020025.
  13. Rao CR, de Ruiter LE, Bhat P, et al. A case-control study on risk factors for preterm deliveries in a secondary care hospital, southern India. ISRN Obstet Gynecol 2014;2014:935982. DOI: 10.1155/2014/935982.
  14. Gonclaves LF, Chaiworapongsa T, Romero R. Intrauterine infection and prematurity. Ment Retard Dev Disabil Res Rev 2002;8(1):3–13. DOI: 10.1002/mrdd.10008.
  15. Lamont RF. Infection in the prediction and antibiotics in prevention of spontaneous preterm labour and preterm birth. BJOG 2003;110(Suppl. 2):71–75. DOI: 10.1016/s1470-0328(03)00034-x.
  16. Onankpa BO, Isezuo K. Pattern of preterm delivery and their outcome in a tertiary hospital. Int J Health Sci Res 2014;4:59–65.
  17. Moreau C, Kaminski M, Ancel PY, et al; EPIPAGE Group. Previous induced abortions and the risk of very preterm delivery: results of the EPIPAGE study. BJOG 2005;112(4):430–437. DOI: 10.1111/j.1471-0528.2004.00478.x.
  18. Iqbal N, Azhar IA, Ahmad I, et al. A study of neonatal outcome associated with preterm birth in a tertiary care hospital. Annals 2013;19(3):231–236.
  19. Satija A, Satija V, Kaur J, et al. Prospective analysis of preterm labor: etiology and outcome. Int J Basic Appl Med Sci 2014;4(2):70–77.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.