Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 14 , ISSUE 2 ( March-April, 2022 ) > List of Articles

Original Article

Distribution and Prevalence of High-risk Human Papillomavirus Infection in Women of Western Uttar Pradesh, India: A Hospital-based Study

Ruchi Mishra, Dakshina Bisht

Citation Information : Mishra R, Bisht D. Distribution and Prevalence of High-risk Human Papillomavirus Infection in Women of Western Uttar Pradesh, India: A Hospital-based Study. J South Asian Feder Obs Gynae 2022; 14 (2):91-94.

DOI: 10.5005/jp-journals-10006-2013

License: CC BY-NC 4.0

Published Online: 21-06-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Aim: Cervical cancer caused by human papillomavirus (HPV) is heterogenic in nature with a regional variation in its distribution. It is crucial to detect high-risk HPV, and thus, the present study aims to find the distribution and prevalence of HPV genotypes by DNA testing and its correlation with cervical cytology. The results of this study would be helpful in the development of newer and efficacious HPV vaccine to make it regionally more specific. Materials and methods: A cross-sectional study was conducted in a tertiary-care hospital. A total of 217 women presented at the outpatient Department of Obstetrics and Gynaecology with different clinical conditions. Women with history of malignancy and pregnancy were excluded from the study. Detailed history was taken on a preformed pro forma, and cervical samples were detected for abnormal cytology by Pap smear and genotyping by HPV DNA testing by polymerase chain reaction. Results: The overall prevalence of HPV was 5.5% (12/217), and HPV types 59, 56, 51, 33 and 18 were found prevalent in this study. The higher number of HPV DNA positivity found was in low-grade squamous intraepithelial lesion constituting (66.6%), followed by inflammatory smear (20.6%) and normal cytology with (1.1%). Conclusion: It has been observed that there is a high prevalence of HPV genotypes 59, 56, 51, 33, and 18. Our study highlights the importance of considering other high-risk genotypes which are not covered by the vaccines currently available in India; therefore, it is necessary to redesign the vaccine by including these genotypes to reduce the incidence of carcinoma cervix.


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  1. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021;71(3):209–249. DOI: 10.3322/caac.21660.
  2. Walboomers JM, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999;189(1):12–19. DOI: 10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F.
  3. Moscicki AB, Schiffman M, Burchell A, et al. Updating the natural history of human papillomavirus and anogenital cancers. Vaccine 2012;30:24–33. DOI: 10.1016/j.vaccine.2012.05.089.
  4. Ermel A, Shew ML, Imburgia TM, et al. Redetection of human papillomavirus type 16 infections of the cervix in mid-adult life. Papillomavirus Res 2018;5:75–79. DOI: 10.1016/j.pvr.2018.01.001.
  5. Datta P, Bhatla N, Dar L, et al. Prevalence of human papillomavirus infection among young women in North India. Cancer Epidemiol 2010;34:157–161. DOI: 10.1016/j.canep.2009.12.016.
  6. Sahasrabuddhe VV, Bhosale RA, Joshi SN, et al. Prevalence and predictors of colposcopic-histopathologically confirmed cervical intraepithelial neoplasia in HIV-infected women in India. PLoS One 2010;5:8634. DOI: 10.1371/journal.pone.0008634.
  7. Datta P, Bhatla N, Pandey RM, et al. Type-specific incidence and persistence of HPV infection among young women: a prospective study in North India. Asian Pac J Cancer Prev 2012;13(3):1019–1024. DOI: 10.7314/apjcp.2012.13.3.1019.
  8. Matah M, Sareen S. Detection of HPV by PCR—a novel step in the prevention of cancer cervix. J Obstet Gynaecol India 2012;62:188–191. DOI: 10.1007/s13224-012-0167-3.
  9. Senapati R, Nayak B, Kar SK, et al. HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India. BMC Infect Dis 2017;17(1):30. DOI: 10.1186/s12879-016-2136-4.
  10. Jovanović AM, Dikic SD, Jovanovic V, et al. Correlation of human papilloma virus infection with cytology, colposcopy and histopathological examination of the bioptic tissue in low- and high-grade intraepithelial lesions. Eur J Gynaecol Oncol 2012;33(5):512–516. PMID: 23185799.
  11. Misra JS, Srivastava S, Singh U, et al. Risk-factors and strategies for control of carcinoma cervix in India: hospital based cytological screening experience of 35 years. Indian J Cancer 2009;46(2):155–159. DOI: 10.4103/0019-509x.49155.
  12. Xu Y, Dotto J, Hui Y, et al. High grade cervical intraepithelial neoplasia and viral load of high-risk human papillomavirus: significant correlations in patients of 22 years old or younger. Int J Clin Exp Pathol 2009;2(2):169–175. PMID: 19079652.
  13. Sontakke BR, Ambulkar PS, Talhar S, et al. Molecular genetic study to detect prevalence of high-risk human papilloma virus strains (type 16 and 18) in cervical lesions and asymptomatic healthy subjects of rural Central India. J Cytol 2019;36(1):32–37. DOI: 10.4103/JOC.JOC_10_18.
  14. Jin XW, Lipold L, Foucher J, et al. Cost-effectiveness of primary HPV testing, cytology and co-testing as cervical cancer screening for women above age 30 years. J Gen Intern Med 2016;31(11):1338–1344. DOI: 10.1007/s11606-016-3772-5.
  15. Basu P, Roychowdhury S, Bafna UD, et al. Human papillomavirus genotype distribution in cervical cancer in India: results from a multi-center study. Asian Pac J Cancer Prev 2009;10(1):27–34. PMID: 19469620.
  16. Sowjanya AP, Jain M, Poli UR, et al. Prevalence and distribution of high-risk human papillomavirus (HPV) types in invasive squamous cell carcinoma of the cervix and in normal women in Andhra Pradesh. India BMC Infect Dis 2005;5:116. DOI: 10.1186/1471-2334-5-116.
  17. Pillai RM, Babu JM, Jissa VT, et al. Region-wise distribution of high-risk human papillomavirus types in squamous cell carcinomas of the cervix in India. Int J Gynecol Cancer 2010;20(6):1046–1051. DOI: 10.1111/IGC.0b013e3181e02fe0.
  18. Bhatla N, Dar L, Patro AR, et al. Human papillomavirus type distribution in cervical cancer in Delhi, India. Int J Gynecol Pathol 2006;25(4):398–402. DOI: 10.1097/01.pgp.0000209574.62081.e4.
  19. Li N, Franceschi S, Howell-jones R, et al. Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: variation by geographical region, histological type and year of publication. Int J Cancer 2011;128(4):927–935. DOI: 10.1002/ijc.25396.
  20. Singhal T. Indian Academy of Pediatrics Committee on Immunisation (IAPCOI) – consensus recommendations on immunization 2008. Indian Pediatr 2008;45(8):635–648. PMID: 18723905.
  21. Meites E, Szilagyi PG, Chesson HW, et al. Human papillomavirus vaccination for adults: updated recommendations of the advisory committee on immunization practices. MMWR Morb Mortal Wkly Rep 2019;68(32):698–702. DOI: 10.15585/mmwr.mm6832a3.
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