Aim: Cervical cancer is the second rank as the most common cancer worldwide. Squamous cell carcinoma (SCC) is the most common histopathology type for cervical cancers. The radiotherapy prognostic and survival rate becomes important information for patients and clinicians. Materials and methods: This is a historical cohort study in patients with stage IIIB cervical SCC at RSUPN Dr Cipto Mangunkusumo or RSCM from 2016 to 2017. Patients are grouped into two: stage IIIB cervical SCC with lymph node enlargement (LNE) and stage IIIB cervical SCC without LNE. Univariate, bivariate, and multivariate analyses were performed. The 1-year survival rate was analyzed using the Kaplan–Meier method. Results: Research subjects were divided into two groups of which 36 patients (47.4%) with LNE and 40 patients (52.6%) without LNE. The radiotherapy response for patients with stage IIIB cervical SCC with LNE is worse than those without LNE, RR 4.26 (1.96–9.27, 95% IK). Sociodemographic and clinicopathologic descriptions were comparable between the two groups. The 1-year survival of patients with stage IIIB cervical SCC without LNE is better than those with LNE, hazard ratio (HR) 9.57 (3.28–27.88 95% IK). Predictor score of ≥2.1 as the cutoff point to determine negative response on radiotherapy was chosen (LR + 2.31, sensitivity 96.3%, specificity 58.3%, and accuracy 77.3%). Conclusion: There was a significant difference in radiotherapy response between the patients with stage IIIB cervical SCC with LNE and without LNE. Clinical significance: To improve the prognosis and efficacy of radiotherapy in patients with LNE, consideration should be given to further studies on the removal of the LNE prior to undergoing radiotherapy.