Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 13 , ISSUE 4 ( July-August, 2021 ) > List of Articles

Original Article

Characteristics and Outcomes of COVID-19 (SARS-CoV-2)Positive Pregnant Women Admitted to a Dedicated COVID Hospital in Central India: A Single-center Observational Study

Sanjay Avashia, Dharmendra Jhavar, Kirti Sinha, Shivam Gupta

Keywords : COVID-19, COVID-19 infection in pregnancy, Maternal and neonatal outcome, Maternal outcome, SARS-CoV-2

Citation Information : Avashia S, Jhavar D, Sinha K, Gupta S. Characteristics and Outcomes of COVID-19 (SARS-CoV-2)Positive Pregnant Women Admitted to a Dedicated COVID Hospital in Central India: A Single-center Observational Study. J South Asian Feder Obs Gynae 2021; 13 (4):245-250.

DOI: 10.5005/jp-journals-10006-1919

License: CC BY-NC 4.0

Published Online: 20-11-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Aim and objective: To identify characteristics of coronavirus disease-2019 (COVID-19) infection in pregnancy, maternal, and fetal outcomes and study changes in inflammatory markers and chest imaging findings. Materials and methods: This study is an observational study on pregnant COVID positive women admitted for treatment in the Maharaja Tukojirao Holkar Dedicated COVID Hospital, Indore, Madhya Pradesh, India from April 17, 2020, to April 30, 2021. There were two notable peaks of infection with different clinical characteristics. Group A included data from April 17, 2020, to February 28, 2021, and group B from March 1, 2021, to April 30, 2021. A detailed comparative analysis was done, comparing clinical parameters, investigational findings, and outcomes in both groups. Results: The incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnant women based on admissions in our hospital was 1.26/1,000 maternities. Group A had 94 cases, while group B that included the second wave of infection had 103 cases. The demographic profile of women was comparable in both groups. About 84.04% of women in group A were asymptomatic. In group B, 27.18% were asymptomatic. Laboratory parameters were deranged more so in group B. In group A, 41.49% of women reported in labor and there were no mortalities. In group B, 25.24% reported in labor, those <31 weeks were 60.64%, and there were 12 mortalities. Cesarean section was done in 56.52% of group A, 39.06% of group B, and there were 12.5% of abortions. All of the babies who delivered by vaginal route or cesarean section tested negative within 12 hours of delivery irrespective of maturity. Conclusion: In our study, we noticed two notable peaks of SARS-CoV-2 infection, first onset was from April 2020 which gradually declined till February 2021 but majority of pregnant women remained asymptomatic, those at term delivered, others recovered within 8 to 14 days, and majority did not require any advanced treatment or oxygen support. Starting from April 2021, there was a resurgence of cases with moderate-to-severe disease, morbidities, and even deaths. All novel management options were given on individualized basis including remdesivir, IVIG, and bevacizumab, which proved to be lifesaving in some. All babies delivered tested were SARS-CoV-2 negative and there was a good neonatal outcome.

  1. World Health Organization. Rolling updates on coronavirus disease (COVID-19). 2020. Available from:
  2. World Health Organization. Naming the coronavirus disease (COVID- 19) and the virus that causes it. 2020. Available from: the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it.
  3. Cabinet Office. Guidance. Staying alert and safe (social distancing). Coronavirus (COVID-19) guidance and support. 2020. Available from: [Accessed May 24, 2020].
  4. RCOG. (COVID-19) infection in pregnancy. Available from:
  5. Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020;395(10226):809–815. DOI: 10.1016/S0140-6736(20)30360-3.
  6. Aylward B, Liang W, Dong X, et al. Report of the WHO China joint mission on coronavirus disease 2019 (COVID-19) [Internet]. Beijing: World Health Organisation; 2020.
  7. Knight M, Bunch K, Vousden N, et al. Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study. BMJ 2020;369:m2107 Available from:
  8. Zambrano LD, Ellington S, Strid P, et al. Update: characteristics of symptomatic women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status – United States, January 22-October 3, 2020. MMWR Morb Mortal Wkly Rep 2020;69(44):1641. DOI: 10.15585/mmwr.mm6944e3.
  9. Allotey J, Stallings E, Bonet M, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ 2020;370:m3320. DOI: 10.1136/bmj.m3320.
  10. Yanes-Lane M, Winters N, Fregonese F, et al. Proportion of asymptomatic infection among COVID-19 positive persons and their transmission potential: a systematic review and meta-analysis. PLoS One 2020;15(11):e0241536. DOI: 10.1371/journal.pone.0241536.
  11. Tremblay E, Thérasse E, Thomassin-Naggara I, et al. Quality initiatives: guidelines for use of medical imaging during pregnancy and lactation. Radiographics 2012;32(3):897. DOI: 10.1148/rg.323115120.
  12. Oshay RR, Chen MYC, Fields BKK, et al. COVID-19 in pregnancy: a systematic review of chest CT findings and associated clinical features in 427 patients. Clin Imaging 2021;75:75. DOI: 10.1016/j.clinimag.2021.01.004.
  13. De Sanctis V, Bedair EMA, Soliman AT, et al. Proposed scoring system for evaluating clinico-radiological severity of COVID-19 using plain chest X-ray (CXR) changes (CO X-RADS): preliminary results. Acta Biomed 2020;91(4):e2020172. DOI: 10.23750/abm.v91i4.10664. PMID: 33525220; PMCID: PMC7927462.
  14. Kotlyar AM, Grechukhina O, Chen A, et al. Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis. Am J Obstet Gynecol 2021;224(1):35. DOI: 10.1016/j.ajog.2020.07.049.
  15. Woodworth KR, Olsen EO, Neelam V, et al. Birth and infant outcomes following laboratory-confirmed SARS-CoV-2 infection in pregnancy – SET-NET, 16 Jurisdictions, March 29-October 14, 2020. MMWR Morb Mortal Wkly Rep 2020;69(44):1635. DOI: 10.15585/mmwr.mm6944e2.
  16. Penfield CA, Brubaker SG, Limaye MA, et al. Detection of severe acute respiratory syndrome coronavirus 2 in placental and fetal membrane samples. Am J Obstet Gynecol MFM 2020;2(3):100133. DOI: 10.1016/j.ajogmf.2020.100133.
  17. Patanè L, Morotti D, Giunta MR, et al. Vertical transmission of coronavirus disease 2019: severe acute respiratory syndrome coronavirus 2 RNA on the fetal side of the placenta in pregnancies with coronavirus disease 2019-positive mothers and neonates at birth. Am J Obstet Gynecol MFM 2020;2(3):100145. DOI: 10.1016/j.ajogmf.2020.100145.
  18. Huntley BJF, Huntley ES, Di Mascio D, et al. Rates of maternal and perinatal mortality and vertical transmission in pregnancies complicated by severe acute respiratory syndrome coronavirus 2 (SARS-Co-V-2) infection: a systematic review. Obstet Gynecol 2020;136(2):303. DOI: 10.1097/AOG.0000000000004010.
  19. Qiu L, Liu X, Xiao M, et al. SARS-CoV-2 is not detectable in the vaginal fluid of women with severe COVID-19 infection. Clin Infect Dis 2020;71(15):813. DOI: 10.1093/cid/ciaa375.
  20. Pique-Regi R, Romero R, Tarca AL, et al. Does the human placenta express the canonical cell entry mediators for SARS-CoV-2? Elife 2020;9:e58716. DOI: 10.7554/eLife.58716.
  21. Hecht JL, Quade B, Deshpande V, et al. SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers. Modern Pathology. 2020 Nov;33(11):2092–2103. Available from:
  22. Rasmussen SA, Lyerly AD, Jamieson DJ. Delaying pregnancy during a public health crisis – examining public health recommendations for Covid-19 and beyond. N Engl J Med 2020;383(22):2097–2099. DOI: 10.1056/NEJMp2027940.
  23. Nambiar SS, Ajith S, Reshmi VP. Assessing disease outcome in COVID-19 pregnancies in a tertiary referral center in South India: a single-center retrospective cohort study. J South Asian Feder Obst Gynae 2020;12(5):335–339. DOI: 10.5005/jp-journals-10006-1822.
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