Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 13 , ISSUE 3 ( May-June, 2021 ) > List of Articles

ORIGINAL RESEARCH

Association of Serum Uric Acid and Serum Calcium with Preeclampsia and Eclampsia

Rekha Wadhwani, Kanchan N Verma, Neetu Ahirwar

Keywords : Case, Control, Eclampsia, Preeclampsia, Serum calcium, Serum uric acid

Citation Information : Wadhwani R, Verma KN, Ahirwar N. Association of Serum Uric Acid and Serum Calcium with Preeclampsia and Eclampsia. J South Asian Feder Obs Gynae 2021; 13 (3):110-113.

DOI: 10.5005/jp-journals-10006-1910

License: CC BY-NC 4.0

Published Online: 09-09-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim and objective: To determine the correlation of serum uric acid and serum calcium with the severity of preeclampsia and eclampsia. Materials and methods: The present case-control study has been carried out for a period of 1 year from March 2018 to February 2019 after institutional ethical clearance. The sample size of the study was 150 cases and 150 controls. This was a case-control study. Cases were admitted patients with preeclampsia or eclampsia. Controls were normotensive pregnant women. On admission, after informed consent, venous serum samples were collected prior to their commencement of intravenous therapy and magnesium sulfate therapy. Blood samples obtained on admission were sent for serum calcium and serum uric acid level estimation, and then, the results were analyzed. Result: The mean serum uric acid among cases was 6.98 ± 1.85 mg/dL, whereas in controls, it was 4.55 ± 1.38 mg/dL; similarly, the mean serum calcium among cases and controls was 8.44 ± 1.1 and 9.87 ± 0.69, respectively. Test of significance observed statistically highly significant difference in mean serum uric acid and serum calcium between cases and controls (p <0.01). The present study observed a significantly higher occurrence of cerebrovascular accident (CVA), and postpartum hemorrhage (PPH) among cases with serum uric acid level greater than 6.2 mg/dL as compared to cases with serum uric acid level less than 6.2 mg/dL (p <0.05). The present study observed that CVA was significantly higher in cases with serum calcium level less than 9 mg/dL (p <0.05). The occurrence of deaths due to pulmonary embolism (PE), pulmonary edema, acute respiratory distress syndrome (ARDS), and multiple organ dysfunction syndrome (MODS) was higher in patients with raised serum uric acid level. Conclusion: The present study found that elevated serum uric acid level could be used as a biochemical marker for preeclampsia and eclampsia. Calcium supplement may help in the reduction of incidence of preeclampsia and eclampsia in country especially where nutrition is poor.


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  1. Cunningham FG, Leveno KG, Bloom SL, et al. Hypertensive disorders in pregnancy. Williams Obstetrics. 22nd ed. Mc Graw Hill; 2005. p. 761–785.
  2. Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet 2005;365(9461):785–799. DOI: 10.1016/S0140-6736(05)17987-2.
  3. Koga K, Osuga Y, Tajima T, et al. Elevated serum soluble fms-like tyrosinekinase 1 (sFlt1) level in women with hydatidiform mole. Fertil Steril 2010;94(1):305–308. DOI: 10.1016/j.fertnstert.2009.02.015.
  4. Bdolah Y, Lam C, Rajakumar A, et al. Twin pregnancy and the risk ofpreeclampsia: bigger placenta or relative ischemia? Am J Obstet Gynecol 2008;198(4):428. DOI: 10.1016/j.ajog.2007.10.783.
  5. Raijmakers MT, Dechend R, Poston L. Oxidative stress and preeclampsia:rationale for antioxidant clinical trials. Hypertension 2004;44(4):374–380. DOI: 10.1161/01.HYP.0000141085.98320.01.
  6. Orhan H, Onderoglu L, Yücel A, et al. Circulating biomarkers of oxidativestress in complicated pregnancies. Arch Gynecol Obstet 2003;267(4):189–195. DOI: 10.1007/s00404-002-0319-2.
  7. Roggensack AM, Zhang Y, Davidge ST. Evidence for peroxynitrite formationin the vasculature of women with preeclampsia. Hypertension 1999;33(1):83–89. DOI: 10.1161/01.hyp.33.1.83.
  8. Kumar N, Singh AK. Maternal serum uric acid and calcium as predictors On hypertensive disorder of pregnancy: A case control study. Taiwanese Journal of Obstetrics and Gynecology. 2019 Mar 1;58(2):244–50.
  9. Toshniwal S, Lamba AR. Serum uric acid as marker of severity of preeclampsia. Int J ReprodContraceptObstetGynececol 2017;6:4915–7 DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20174999.
  10. Ephraim RK, Osakunor DN, Denkyira SW, Eshun H, Amoah S, Anto EO. Serum calcium and magnesium levels in women presenting with preeclampsia and pregnancy-induced hypertension: a case–control study in the Cape Coast metropolis, Ghana. BMC pregnancy and childbirth. 2014 Dec;14(1):390.
  11. Manjareeka M, Nanda S. Elevated levels of serum uric acid, creatinine or urea in preeclamptic women. Int J Med Sci Public Health. 2013 Jan 1;2(1):43–7. DOI:10.5455/ijmsph.2013.2.43.47.
  12. Nair et al. Estimation of Serum Uric Acid as an Indicator of Severity of Preeclampsia and Perinatal Outcome 2017 JOGI Apr;67(2):109-118. DOI: 10.1007/s13224-016-0933-8. Epub 2016 Sep 9.
  13. Kao PC, Shiesh SC, Wu TJ. Serum C-reactive protein as a marker for wellness assessment. Ann Clin Lab Sci 2006;36(2):163–169. DOI: 0091-7370/06/0100-0163.$1.75.c 2006 by association of clinical scientist, inc.
  14. Sirajwala HB, Sharma D, Agravatt AM. A study of serum total calcium and uric acid levels in preeclampsia. Indian Journal of Basic and Applied Medical Research. 2013 Dec;3(1):50-6.
  15. Jialal I, Stein D, Balis D, et al. Effect of hydroxymethyl glutaryl coenzyme A reductase inhibitor therapy on highsensitive C-reactive protein levels. Circulation 2001;103(15):1933–1935. DOI: 10.1161/01. cir.103.15.1933.
  16. Asgharnia M, Mirblouk F, Kazemi S, Pourmarzi D, Keivani MM, Heirati SF. Maternal serum uric acid level and maternal and neonatal complications in preeclamptic women: A cross-sectional study. International Journal of Reproductive BioMedicine. 2017 Sep;15(9):583.
  17. Tejal P, Astha D. Relationship of serum uric acid level to maternal and perinatal outcome in patients with hypertensive disorders of pregnancy. Gujarat Medical Journal. 2014;69(2):1–3.
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