Journal of South Asian Federation of Obstetrics and Gynaecology

Register      Login

VOLUME 13 , ISSUE 1 ( January-February, 2021 ) > List of Articles

RESEARCH ARTICLE

Maternal and Neonatal Outcomes of Pregnant Women with COVID-19: A Case–Control Study at a Tertiary Care Center in India

Moushmi Parpillewar Tadas, S Prashanthi, Manjushree Waikar

Keywords : Case–Control, COVID-19 in pregnancy, Maternal and neonatal outcome, Medical morbidity, Pregnancy-related morbidity

Citation Information : Tadas MP, Prashanthi S, Waikar M. Maternal and Neonatal Outcomes of Pregnant Women with COVID-19: A Case–Control Study at a Tertiary Care Center in India. J South Asian Feder Obs Gynae 2021; 13 (1):44-49.

DOI: 10.5005/jp-journals-10006-1850a

License: CC BY-NC 4.0

Published Online: 00-02-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim and background: Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), how it affects pregnancy very little is known. To identify maternal and neonatal risks associated with COVID-19 in pregnancy and to describe outcome a matched case–control study was done. Materials and methods: In this study, COVID-19 reverse transcription polymerase chain reaction (RT-PCR) positive women who delivered from May 1, 2020, to August 31, 2020, were included. Cases were classified according to their severity and investigations. Controls were selected from COVID-19 negative women in a 1:1 ratio who delivered in the study period. Data were collected, analyzed in terms of maternal and neonatal outcomes. Results: Of the total 181 COVID-19 cases delivered during the study period, there were 97.23% mild, 2.76% moderate, and 0.55% severe cases. A total of 178 (98.34%) were diagnosed in the third trimester. More COVID-19 cases were from urban areas. Mean gestational age in the mild category was 38.1 weeks and the moderate/severe category was 37.5 weeks. Around 154 (85.08%) were asymptomatic. Cases had more medical and pregnancy morbidity than controls, which was statistically significant. About 52.49% of cases and 33% of controls had cesarean. Length of hospital stay was more in cases. Mean birth weight was 2.7 ± 0.59 kg in cases and 2.5 ± 0.56 kg in control. There were 7 stillbirths in each group. A total of 14 in cases and 16 in controls were transferred to the newborn intensive care unit (NICU). Conclusion: The majority of COVID-19 infected women who are asymptomatic are in the mild category and there are no adverse maternal and neonatal outcomes due to the disease. The adversity of maternal and neonatal outcomes depends on the severity and severity of the disease is dependent on advanced maternal age and presence of comorbidities.


PDF Share
  1. Su S, Wong G, Shi W, et al. Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends Microbiol 2016;24(6):490–502. DOI: 10.1016/j.tim.2016.03.003.
  2. Ksiazek TG, Erdman D, Goldsmith CS, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003;348(20):1953–1966. DOI: 10.1056/NEJMoa030781.
  3. World Health Organization. Middle East respiratory syndrome coronavirus (MERS-CoV). 2019. http://www.who.int/emergencies/merscov/en/. Accessed March 25, 2020.
  4. Coronavirus disease (COVID-19) events as they happen [Internet]. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/event s-as-they-happen. Accessed 23 May, 2020.
  5. World Health Organization. Coronavirus disease 2019 (COVID19) Situation Report—48. World Health Organization. https://www.who.int/docs/default-source/coronavirus/situation-reports/20200308-sitrep-48-covid-19.pdf?sfvrsn=16f7ccef_4. March 8, 2020; Accessed 9 March, 2020.
  6. Coronavirus Update (Live): Virus Pandemic Worldometer [Internet]. https://www.worldometers.info/coronavirus. Accessed 27 October, 2020.
  7. Khoiwal K, Kapur D, Gaurav A, et al. Management of pregnant women in times of Covid-19: a review of current literature. J Obstet Gynecol India 2020;70(4):262–266. DOI: 10.1007/s13224-020-01342-4.
  8. Poon LC, Yang H, Kapur A, et al. Global interim guidance on coronavirus disease 2019 (COVID-19) during pregnancy and puerperium from FIGO and allied partners: information for healthcare professionals. Int J Gynecol Obstet 2020;149(3): 273–286. DOI: 10.1002/ijgo.13156.
  9. Liu H, Liu F, Li J, et al. Clinical and CT imaging features of the COVID-19 pneumonia: focus on pregnant women and children. J Infect 2020;80(5):e7–e13. DOI: 10.1016/j.jinf.2020.03.007.
  10. Zhu H, Wang L, Fang C, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr 2020;9(1):51–60. DOI: 10.21037/tp.2020.02.06.
  11. Nayak AH, Kapote DS, Fonseca M, et al. Impact of the coronavirus infection in pregnancy: a preliminary study of 141 patients. J Obstet Gynecol India 2020;70(4):256–261. DOI: 10.1007/s13224-020-01335-3.
  12. https://www.mohfw.gov.in/pdf/UpdatedClinicalManagementProtocolforCOVID19dated03072020.pdf.
  13. Li N, Han L, Peng M, et al. Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case–control study. Clin Infect Dis 2020;71(16):2035–2041. DOI: 10.1093/cid/ciaa352.
  14. Wang Z, Wang Z, Xiong G. Clinical characteristics and laboratory results of pregnant women with COVID‐19 in Wuhan, China. Int J Gynecol Obstet 2020;150(3):312–317. DOI: 10.1002/ijgo.13265.
  15. Brandt JS, Hill J, Reddy A, et al. Epidemiology of COVID-19 in pregnancy: risk factors and associations with adverse maternal and neonatal outcomes. Am J Obstet Gynecol 2020;224(4):P389.E1–P389.E9. DOI: 10.1016/j.ajog.2020.09.043.
  16. Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine Vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020;395(10226):809–815. DOI: 10.1016/S0140-6736(20)30360-3.
  17. Yu N, Li W, Kang Q, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect Dis 2020;20(5):559–564. DOI: 10.1016/S1473-3099(20)30176-6.
  18. Sachin D, Tanacan A, Erol SA, et al. A pandemic center's experience of managing pregnant women with COVID‐19 infection in Turkey: a prospective cohort study. Int J Gynecol Obstet 2020;151(1):74–82. DOI: 10.1002/ijgo.13318.
  19. Knight M, Bunch K, Vousden N, et al. Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study. BMJ 2020;369:m2107. DOI: 10.1136/bmj.m2107.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.