Journal of South Asian Federation of Obstetrics and Gynaecology

Register      Login

VOLUME 12 , ISSUE 1 ( January-February, 2020 ) > List of Articles

Original Article

Study of Prolactin in Cervicovaginal Secretion in Women with Preterm Labor and Normal Pregnancy

Seema Mehrotra, Vandana Solanki, SM Natu, Shilpi Chauhan, Ruchita Sharma

Citation Information : Mehrotra S, Solanki V, Natu S, Chauhan S, Sharma R. Study of Prolactin in Cervicovaginal Secretion in Women with Preterm Labor and Normal Pregnancy. J South Asian Feder Obs Gynae 2020; 12 (1):34-37.

DOI: 10.5005/jp-journals-10006-1758

License: CC BY-NC 4.0

Published Online: 08-08-2020

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Objective: To evaluate the diagnostic value of cervicovaginal prolactin levels for predicting preterm delivery in women with preterm labor. Materials and methods: The preterm labor group and normal pregnancy group consisted of 75 and 150 patients between 24 weeks and 36 weeks of gestation. The preterm group was further subdivided into two groups. Study group Ia: patients who came up with preterm labor and given tocolytic but had preterm delivery (n = 50). Study group Ib: patients who came up with preterm labor and given tocolytic and delivered full term (n = 25). A single cervicovaginal measurement was made in all the groups. Results: Cervicovaginal prolactin was highest in the study group Ia (11 ± 9.31 ng/mL) as compared to the study group Ib (4.61± 6.2 ng/mL) and control group (2.51 ± 5.1 ng/mL), and the difference was statistically significant (p = 0.0311; p = 0.0000). The optimal cut-off value of prolactin was greater than 7 ng/mL in study group Ia with sensitivity level of 78%, at a specificity of 80% with positive and negative predictive values of 88.64% and 64.52%, respectively. The area under the receiver operating characteristic (ROC) curve was 79% which indicates fair diagnostic accuracy of cervicovaginal prolactin in predicting preterm labor. Conclusion: Prolactin is a potential biochemical marker which can be used alone or complementary to other markers for predicting preterm labor.


PDF Share
  1. Lawn JE, Wilczynska-Ketende K, Cousens SN. Estimating the causes of 4 million neonatal deaths in the year 2000. Int J Epidemiol 2006;35(3):706–718. DOI: 10.1093/ije/dyl043.
  2. Petrou S, Mehta Z, Hockley C, et al. The impact of pretum birth on hospital inpatient admissions and casts during the first 5 years of life. Peadiatrics 2003;112(6 Pt 1):19290–19297.
  3. Petrou S. The economic consequences of preterm birth during the first 10 years of life. BJOG 2005;112(Suppl 1):10–15. DOI: 10.1111/j.1471-0528.2005.00577.x.
  4. Beck S, Wojdyla D, Say L, et al. The worldwide incidence of preterm birth. A systematic review of maternal mortality and mobidity. WHO Bull 2010;88(1):31–38.
  5. WHO collaborating centre for training and research in newborn care. National neonatal perinatal database network. National neonatal perinatal- database report 2002–2003. India National neonatology forum NNPD network; 2005.
  6. Florio P, Linton EA, Torricellie M, et al. Prediction of preterm delivery based on maternal plasma Urocortin. J Clin Endocrinol Metab 2007;92(12):4734–4737. DOI: 10.1210/jc.2007-0457.
  7. Malak TM, Sizmer F, Bell SC, et al. Fetal fibronectin in cervicovaginal secretions as a prediction of preterm birth. BJOG 1996;10(7):648–653. DOI: 10.1111/j.1471-0528.1996.tb09832.x.
  8. Paternoster DM, Muresan D, Vitul A, et al. Cervical phIGFBP-1 in the evaluation of the risk of preterm delivery. Acta Obstet Gynecol Scand 2007;86(2):151–155. DOI: 10.1080/00016340600935730.
  9. Zegels G, Van Raemdonck GAA, Tjalma WAA, et al. Use of cervicovaginal fluid for the identification of biomarkers for pathologies of the female genital tract. Proteome Sci 2010;8:63. DOI: 10.1186/1477-5956-8-63.
  10. Anai T, Tanakay, Hirota Y, et al. Vaginal fluid HCG levels for detecting premature rupture of membranes. Obstet Gynecol 1997;89(2): 261–264. DOI: 10.1016/S0029-7844(96)00448-6.
  11. Leitich H, Egartu C, Kaider A, et al. Cervicovaginal fetal fibronectin as a marker for preterm delivery: a meta analysis. Am J obstet Gynecol 1999;180(5):1169–1176. DOI: 10.1016/S0002-9378(99)70612-5.
  12. Maaskant RA, Bogic LV, Gilger S, et al. The human prolactin receptor in the fetal membranes, decidua and placenta. J Clin Endocrinol Metab 1996;81(1):396–405. DOI: 10.1210/jcem.81.1.8550784.
  13. Hauth JC, Parker Jr. CR, Mac Donald PC, et al. A role of fetal prolactin in lung maturation. Obstect Gynecol 1978;51(1):81–88. DOI: 10.1097/00006254-197808000-00002.
  14. Riddick DH, Luciano AA, Kusmik W, et al. De novo synthesis of prolactin by human decidua. Life Sci 1978;23(19):1913–1921. DOI: 10.1016/0024-3205(78)90557-X.
  15. O' Brien JM, Peeler G, Pitts DW, et al. Cervicovaginal prolactin: a marker for spontaneous preterm delivery. Am obstet Gynecol 1994;171(4):1107–1111. DOI: 10.1016/S0002-9378(13)90045-4.
  16. Guvenal T, Kantas E, Erselcan T, et al. Beta-human chronic gonadotrophs and prolactin assays in cervicovaginal secretions as a predictor of preterm delivery. Int J Gynaecol Obstet 2001;75(3): 229–234. DOI: 10.1016/S0020-7292(01)00495-7.
  17. Buyukbayrak EE, Turan C, Unal O, et al. Diagnostic power of the vaginal washing –fluid prolactin assay as an alternative method for the diagnosis of premature rupture of membranes. J Matern Fetal Neonatal Med 2004;15(2):120–125. DOI: 10.1080/14767050410001659842.
  18. Kariman N, Hedayati M, Majd SHA. The role of vaginal prolactin in diagnosis of premature rupture of membranes. Acta obstet Gynecol Scand 2005;84(8):802–805.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.